Effect of o-(beta-hydroxyethyl)-rutoside in lymphangiography

In 30 patients who underwent lymphography of the retroperitoneal lymph nodes, the lymph vessels of one leg were pretreated with 5 ml of 10% o(beta-hydroxyethyl)-rutoside (HR) prior to administration of Lipiodol Ultrafluid. There were no untoward clinical effects associated with the pretreatment. Legs pretreated with HR showed significantly fewer extravasations of contrast material than those untreated. HR appears to reduce the permeability of the lymph vessels, thus preventing or diminishing the occurrence of extravasations.