Clinicopathological Analysis of Patients with Isolated Hematuria and/or Mild Proteinuria

This investigation aimed to explore the clinicopathological features of patients with isolated hematuria and/or mild proteinuria in kidney disease.

We conducted a retrospective review of the clinical and pathological information of patients initially diagnosed with chronic nephritis syndrome in the Nephrology Department of Yuebei People's Hospital.

In total, 227 participants were recruited for the study, including 79 patients (34.8%) in the group with isolated hematuria and/or mild proteinuria and 148 patients (65.2%) in the group with medium-large amounts of proteinuria. There were 29 cases (36.7%) of IgA nephropathy, seven cases (8.9%) of focal segmental glomerulosclerosis, six cases (7.6%) of membranous nephropathy, and six cases (7.9%) of acute renal tubular injury in the group with isolated hematuria and/or mild proteinuria. The common pathological types in the medium-large proteinuria group were membranous nephropathy in 68 cases (45.9%), minimal change nephropathy in 25 cases (16.9%), and IgA nephropathy in 20 cases (13.5%).

IgA nephropathy is the main pathological type in the group with isolated hematuria and/or mild proteinuria, while membranous nephropathy is the common pathological type in the group with moderate to severe proteinuria. There was a significantly stronger correlation between the level of hematuria/proteinuria and both BMI and MAP.