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Related Concept Videos

Development of the Heart01:27

Development of the Heart

708
The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart...
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Charting Postnatal Heart Development Using In Vivo Single-Cell Functional Genomics.

Haofei Wang, Yanhan Dong, Yiran Song

    Biorxiv : the Preprint Server for Biology
    |March 31, 2025
    PubMed
    Summary
    This summary is machine-generated.

    Researchers mapped postnatal heart development, revealing key regulators of cardiomyocyte maturation. They developed a new high-throughput method, Probe-based Indel-detectable Perturb-seq (PIP-seq), to discover gene functions in vivo.

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    Area of Science:

    • Cardiovascular Biology
    • Developmental Biology
    • Genomics

    Background:

    • Postnatal heart development involves complex remodeling of cardiac cells.
    • Understanding cardiomyocyte maturation is crucial for cardiac health.
    • Regulatory mechanisms governing this process are not fully understood.

    Purpose of the Study:

    • To create a comprehensive atlas of postnatal heart development.
    • To identify novel regulators of cardiomyocyte maturation.
    • To develop a high-throughput method for functional genetic screening in vivo.

    Main Methods:

    • Integrated single-nucleus and spatial transcriptomics for a temporal-spatial atlas.
    • Developed Probe-based Indel-detectable Perturb-seq (PIP-seq) for high-throughput functional genomics.
    • Applied PIP-seq to study postnatal cardiac development.

    Main Results:

    • Generated a dynamic atlas of cardiomyocyte maturation.
    • Identified 21 novel regulators of cardiomyocyte maturation.
    • Demonstrated PIP-seq's capability for in vivo gene function analysis.

    Conclusions:

    • Established a high-resolution framework for postnatal heart development research.
    • Highlighted the roles of microenvironment and intercellular communication in maturation.
    • PIP-seq provides a powerful tool for exploring gene function in complex biological processes.