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Development of the Heart

Development of the Heart

The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart...

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Related Experiment Video

Updated: May 17, 2025

Noninvasive Electrocardiography in the Perinatal Mouse

Noninvasive Electrocardiography in the Perinatal Mouse

Published on: June 12, 2020

Charting Postnatal Heart Development Using In Vivo Single-Cell Functional Genomics.

Haofei Wang, Yanhan Dong, Yiran Song

Biorxiv : the Preprint Server for Biology

|March 31, 2025

Summary

This summary is machine-generated.

Researchers mapped postnatal heart development, revealing key regulators of cardiomyocyte maturation. They developed a new high-throughput method, Probe-based Indel-detectable Perturb-seq (PIP-seq), to discover gene functions in vivo.

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Last Updated: May 17, 2025

Noninvasive Electrocardiography in the Perinatal Mouse

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Published on: June 12, 2020

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Murine Fetal Echocardiography

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Published on: February 15, 2013

Area of Science:

Cardiovascular Biology
Developmental Biology
Genomics

Background:

Postnatal heart development involves complex remodeling of cardiac cells.
Understanding cardiomyocyte maturation is crucial for cardiac health.
Regulatory mechanisms governing this process are not fully understood.

Purpose of the Study:

To create a comprehensive atlas of postnatal heart development.
To identify novel regulators of cardiomyocyte maturation.
To develop a high-throughput method for functional genetic screening in vivo.

Main Methods:

Integrated single-nucleus and spatial transcriptomics for a temporal-spatial atlas.
Developed Probe-based Indel-detectable Perturb-seq (PIP-seq) for high-throughput functional genomics.
Applied PIP-seq to study postnatal cardiac development.

Main Results:

Generated a dynamic atlas of cardiomyocyte maturation.
Identified 21 novel regulators of cardiomyocyte maturation.
Demonstrated PIP-seq's capability for in vivo gene function analysis.

Conclusions:

Established a high-resolution framework for postnatal heart development research.
Highlighted the roles of microenvironment and intercellular communication in maturation.
PIP-seq provides a powerful tool for exploring gene function in complex biological processes.