Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Considerations for Pre-deployment Planning in Point-of-Care Ultrasound Program Implementation: A HIMSS-SIIM Enterprise Imaging Community Whitepaper in Collaboration with AIUM.

Journal of imaging informatics in medicine·2026
Same author

Twist1 overexpression models an aggressive subtype of pancreatic ductal adenocarcinoma in vivo.

Lab animal·2026
Same author

Transient gingival inflammation is associated with epithelial dysfunction and systemic immune activation beyond clinical improvement.

Journal of periodontology·2026
Same author

Assessing the Impact of Female Genital Mutilation/Cutting on Genital Inflammation and Microbiota Among Kenyan Female Sex Workers.

American journal of reproductive immunology (New York, N.Y. : 1989)·2026
Same author

GLIS3 marks a neural-like progenitor cell state that drives metastasis in pancreatic ductal adenocarcinoma.

Cell reports·2026
Same author

Distinct Malignant Cell States and Myeloid Glutamate Signaling Associated with Aggressive Pancreatic Neuroendocrine Tumors.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same journal

A human-specific genetic modifier reconfigures large-scale cortical network dynamics underlying behavioral performance.

bioRxiv : the preprint server for biology·2026
Same journal

<i>Staphylococcus aureus</i> uses a eukaryotic-like uridyltransferase to make UDP-GlcNAc for cell wall synthesis.

bioRxiv : the preprint server for biology·2026
Same journal

Dynamic redistribution of eIF4F controls cap-dependent translation initiation.

bioRxiv : the preprint server for biology·2026
Same journal

When does additional information improve accuracy of RNA secondary structure prediction?

bioRxiv : the preprint server for biology·2026
Same journal

Normative brain-state trajectories reveal deviation from healthy aging in Alzheimer's disease.

bioRxiv : the preprint server for biology·2026
Same journal

Noradrenergic infraslow rhythm during sleep is the critical link between heart-rate dynamics and memory consolidation.

bioRxiv : the preprint server for biology·2026
See all related articles

Related Experiment Video

Updated: May 17, 2025

Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers
03:37

Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers

Published on: March 1, 2024

614

Integrated spatial morpho-transcriptomics predicts functional traits in pancreatic cancer.

Dennis Gong, Rachel Liu, Yi Cui

    Biorxiv : the Preprint Server for Biology
    |March 31, 2025
    PubMed
    Summary
    This summary is machine-generated.

    Cell morphology analysis reveals new insights into pancreatic cancer. Distinct cell shapes and organization patterns in patient-derived models correlate with drug resistance and metastatic potential, aiding precision oncology.

    More Related Videos

    Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
    07:47

    Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies

    Published on: September 15, 2023

    1.4K
    A Streamlined Approach for Mass Spectrometry-Based Proteomics Using Selected Tissue Regions
    08:59

    A Streamlined Approach for Mass Spectrometry-Based Proteomics Using Selected Tissue Regions

    Published on: April 18, 2025

    285

    Related Experiment Videos

    Last Updated: May 17, 2025

    Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers
    03:37

    Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers

    Published on: March 1, 2024

    614
    Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
    07:47

    Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies

    Published on: September 15, 2023

    1.4K
    A Streamlined Approach for Mass Spectrometry-Based Proteomics Using Selected Tissue Regions
    08:59

    A Streamlined Approach for Mass Spectrometry-Based Proteomics Using Selected Tissue Regions

    Published on: April 18, 2025

    285

    Area of Science:

    • Oncology
    • Cell Biology
    • Genomics

    Background:

    • Patient-derived cell lines are crucial for identifying cancer biomarkers and therapeutic targets.
    • Characterization of cellular morphology in these models remains underexplored.
    • Understanding morphological properties can enhance the utility of in vitro models.

    Purpose of the Study:

    • To investigate the association between cell morphology and drug sensitivity, gene expression, and functional properties in human pancreatic adenocarcinoma (PDAC) cell lines.
    • To identify morphological changes indicative of drug resistance.
    • To explore the prognostic value of cell organization patterns in PDAC tissues.

    Main Methods:

    • Integrated live-cell imaging and spatial mRNA analysis.
    • Categorized PDAC cell lines into morphological and organizational subtypes.
    • Analyzed gene expression, drug sensitivity, and metastatic potential across subtypes.
    • Examined prognostic expression signatures in human PDAC tissues.

    Main Results:

    • Identified KRAS inhibitor-induced morphological changes specific to drug-resistant cells, correlating with gene expression.
    • Classified PDAC cell lines into distinct morphological and organizational subtypes.
    • Found significant differences in gene expression, therapeutic targeting, and metastatic potential among subtypes.
    • Discovered prognostic expression signatures linked to specific cancer cell organization patterns in tissues.

    Conclusions:

    • Cell morphology provides valuable information for understanding pancreatic adenocarcinoma biology.
    • Morphological and organizational subtypes of PDAC cell lines exhibit distinct molecular and functional characteristics.
    • Morphological profiling offers a rapid, cost-effective approach to enhance precision oncology using patient-derived models and tissues.