[Interaction of liposomes with a varying lipid composition with hepatocytes in vitro]

Interaction of liposomes from egg lecithin, phospholipids and gangliosides of rat liver with rat hepatocyte monolayers was investigated. It was shown that liposomes from phospho- and glycolipids of the liver were bound by rat hepatocytes to a far greater degree than lecithin liposomes. Liver gangliosides increased active endocytosis of liposomes by hepatocytes. Preincubation of hepatocytes with gangliosides reduced the binding of phosphoglycolipid liposomes by those cells.