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Updated: May 16, 2025

Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model
Published on: August 29, 2012
[Ocular graft versus host disease]
Philipp Steven1, Tina Dietrich-Ntoukas2
1Kompetenzzentrum okuläre GVHD, Klinik I für Innere Medizin, Centrum für Integrierte Onkologie, Zentrum für Augenheilkunde, Medizinische Fakultät Universität zu Köln und Uniklinik Köln, Kerpenerstr. 62, 50937, Köln, Deutschland. philipp.steven@uk-koeln.de.
Abstract:
Ocular graft versus host disease (GVHD) following allogeneic hematopoietic stem cell transplantation (HSCT) is predominantly an inflammatory and destructive ocular surface disease with increasing incidence. It not only leads to a reduced quality-of-life but can also impair vision and in severe cases lead to blindness. The occurrence of GVHD can lead to a severe, often refractory disorders of the ocular surface, which is associated with chronic inflammation. The occurrence of corneal involvement is a major problem. The establishment of comprehensive care structures and individually adapted stage-appropriate treatment in interdisciplinary collaboration with colleagues in hemato-oncology is therefore of particular importance.
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