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Articles linked to this work by shared authors, journal, and citation graph.

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Prospective evaluation of patient reported outcome measures (PROMs) and correlation with clinical parameters of chronic ocular graft-versus-host disease (GVHD).

The ocular surface·2026
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[Adjuvant Crosslinking to Improve Graft Survival after High-Risk Keratoplasty - A Case Series from the CrossCornealVision Study].

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Bilateral visual impairment caused by Toxoplasma gondii encephalitis and ocular GVHD in a patient after allo-HSCT.

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Real-world evaluation of belumosudil for chronic ocular graft-versus-host-disease: Efficacy and outcomes.

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Related Experiment Video

Updated: May 16, 2025

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[Ocular graft versus host disease].

Philipp Steven1, Tina Dietrich-Ntoukas2

  • 1Kompetenzzentrum okuläre GVHD, Klinik I für Innere Medizin, Centrum für Integrierte Onkologie, Zentrum für Augenheilkunde, Medizinische Fakultät Universität zu Köln und Uniklinik Köln, Kerpenerstr. 62, 50937, Köln, Deutschland. philipp.steven@uk-koeln.de.

Die Ophthalmologie
|March 31, 2025
PubMed
Summary
This summary is machine-generated.

Ocular graft-versus-host disease (GVHD) after stem cell transplants causes severe eye surface inflammation and vision loss. Early, tailored, interdisciplinary care is crucial for managing this condition.

Keywords:
Allogeneic hematopoetic stem cell transplantationChronic inflammationCorneal involvementOcular surface diseaseWetting disorder

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Area of Science:

  • Ophthalmology
  • Hematology
  • Immunology

Background:

  • Ocular graft-versus-host disease (GVHD) is an increasing complication following allogeneic hematopoietic stem cell transplantation (HSCT).
  • This condition is characterized by chronic inflammation and destructive changes to the ocular surface.
  • Corneal involvement is a significant and challenging aspect of ocular GVHD.

Purpose of the Study:

  • To highlight the impact of ocular GVHD on patient quality of life and vision.
  • To emphasize the need for specialized, stage-appropriate treatment strategies.
  • To underscore the importance of interdisciplinary collaboration in managing ocular GVHD.

Main Methods:

  • Review of current literature on ocular GVHD.
  • Analysis of clinical presentation and management challenges.
  • Discussion of treatment paradigms in the context of HSCT.

Main Results:

  • Ocular GVHD significantly reduces quality of life and can lead to severe vision impairment or blindness.
  • The disease often presents as refractory ocular surface disorders with chronic inflammation.
  • Corneal complications are a major concern in the management of ocular GVHD.

Conclusions:

  • Comprehensive care structures are essential for effective management.
  • Individually adapted, stage-appropriate treatment is critical.
  • Interdisciplinary collaboration between ophthalmologists and hemato-oncologists is paramount for optimal patient outcomes.