Related Experiment Video

Updated: May 16, 2025

Flow Cytometric Analysis of Mitochondrial Reactive Oxygen Species in Murine Hematopoietic Stem and Progenitor Cells and MLL-AF9 Driven Leukemia
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Flow Cytometric Analysis of Mitochondrial Reactive Oxygen Species in Murine Hematopoietic Stem and Progenitor Cells and MLL-AF9 Driven Leukemia

Published on: September 5, 2019

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Therapeutic innovations: targeting ROS production in AML with natural and synthetic compounds

Mohammed Hashim Mohammed1, Raed Fanoukh Aboqader Al-Aouadi2, Subasini Uthirapathy3

  • 1Medical Laboratory Techniques Department, College of Health and Medical Technology, Al-Maarif University, Anbar, Iraq. Muhammad.hashem@uoa.edu.iq.

Naunyn-Schmiedeberg'S Archives of Pharmacology
|March 31, 2025
PubMed

Insights

Reactive oxygen species (ROS) impact acute myeloid leukemia (AML) by influencing cell pathways. Targeting ROS offers therapeutic potential but faces challenges in clinical application for AML treatment.

Area of Science:

  • Oncology
  • Biochemistry
  • Cell Biology

Background:

  • Reactive oxygen species (ROS) have a complex role in acute myeloid leukemia (AML) pathophysiology.
  • ROS act as both signaling molecules and mediators of cellular damage in AML.

Purpose of the Study:

  • To provide an in-depth analysis of ROS production in AML.
  • To explore the impact of ROS on cellular pathways governing survival, proliferation, and apoptosis.
  • To assess pharmacological agents targeting ROS and identify ROS-associated prognostic biomarkers.

Main Methods:

  • Literature review of ROS production and function in AML.
  • Analysis of natural and synthetic agents modulating ROS.
  • Identification of prognostic biomarkers linked to ROS.

Main Results:

  • ROS significantly influence key cellular pathways in AML.
  • Pharmacological agents targeting ROS show therapeutic promise but present clinical challenges.
  • ROS-associated biomarkers can aid in patient stratification for AML.

Conclusions:

  • Targeting ROS pathways in AML holds therapeutic potential.
  • Further research is needed to overcome challenges like ROS dynamics and resistance mechanisms.
  • Refining ROS-targeted strategies is crucial for improving AML treatment outcomes.
Keywords:
AMLCancer therapyOxidative stressROS

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