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Network structure and temporal stability of symptoms during perioperative period among gastrointestinal cancer patients

  • 0School of Nursing and Rehabilitation, Shandong University, 44 Wenhua West Road, Jinan, Shandong, 250012, People's Republic of China.
Journal of Cancer Survivorship : Research and Practice +

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March 31, 2025

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March 31, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Gastrointestinal cancer patients experience interconnected perioperative symptoms. Dry mouth and depression are key symptoms requiring prioritized management for better patient outcomes.

Area Of Science

  • Oncology
  • Psychology
  • Health Services Research

Background

  • Perioperative symptom management is crucial for gastrointestinal (GI) cancer patients.
  • Understanding the dynamic relationships between symptoms can improve personalized care strategies.
  • The network structure and temporal stability of perioperative symptoms in GI cancer are not well understood.

Purpose Of The Study

  • To explore the dynamic symptom connections in perioperative GI cancer patients.
  • To identify core symptoms within the perioperative period.
  • To support clinical decision-making for symptom management.

Main Methods

  • Utilized the M.D. Anderson Symptoms Inventory-Gastrointestinal Cancer Module (MDASI-GI) for data collection.
  • Employed a Multilevel Vector Autoregressive (mlVAR) model to construct temporal and contemporaneous symptom networks.
  • Data collected at five time points: pre-surgery (T0) and post-surgery (T1-T4).

Main Results

  • Dry mouth emerged as a core symptom, significantly predicting pain, sadness, difficulty swallowing, distress, and fatigue.
  • Depression was identified as a core symptom in the contemporaneous network, with strong correlations between distress and sadness.
  • Core symptoms varied over time, including appetite loss, distress, and sadness.

Conclusions

  • Positive predictive and associative effects are prevalent among perioperative symptoms in GI cancer patients.
  • Emotional symptoms (depression, sadness) and GI symptoms (dry mouth) are central to the symptom network.
  • Prioritizing management of core symptoms like dry mouth and depression is recommended for improved perioperative care.

Keywords:

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