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Salvage therapy of complicated Candida albicans spondylodiscitis with Rezafungin

Nina Grasselli Kmet1,2, Roberto Luzzati3, Jacopo Monticelli4

  • 1Infectious Diseases Department, University Medical Centre, Ljubljana, Slovenia. nina.grasselli@kclj.si.

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
|March 31, 2025
PubMed

Insights

This case study highlights the successful outpatient treatment of Candida albicans spondylodiscitis using rezafungin. This new echinocandin offers a weekly administration option for managing complex invasive fungal infections.

Area of Science:

  • Infectious Diseases
  • Mycology
  • Pharmacology

Background:

  • Invasive fungal infections, especially Candida species, are a growing cause of hospital-related illness and death.
  • Candida species are the most frequent culprits behind candidemia and invasive candidiasis.

Purpose of the Study:

  • To report a complex case of Candida albicans spondylodiscitis.
  • To document the first use of rezafungin in an outpatient setting for this condition.

Main Methods:

  • A case report detailing the diagnosis and treatment of Candida albicans spondylodiscitis.
  • Treatment with rezafungin, a novel echinocandin with weekly administration suitability.

Main Results:

  • Successful treatment of Candida albicans spondylodiscitis was achieved with rezafungin.
  • The patient received weekly outpatient administration of rezafungin.

Conclusions:

  • Rezafungin shows potential for managing complex fungal infections like Candida albicans spondylodiscitis in an outpatient setting.
  • This case establishes a precedent for using rezafungin in ambulatory care for invasive fungal infections.

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