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Doxifluridine promotes host longevity through bacterial metabolism

Rui Wei1, Yuling Peng1, Yamei Luo1

  • 1State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Plos Genetics
|March 31, 2025
PubMed
Summary

Doxifluridine, a novel drug, rescues age-related alternative splicing defects and extends lifespan in C. elegans. Its efficacy relies on bacterial metabolism, highlighting a drug-host-microbiome interaction crucial for aging research.

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