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Updated: May 16, 2025

The Visual Colorimetric Detection of Multi-nucleotide Polymorphisms on a Pneumatic Droplet Manipulation Platform
Published on: September 27, 2016
Biosensing of single-nucleotide polymorphism: Technological advances and their transformative applications on health
Seyed Majid Hosseini Aghouzi1, Esma Yildiz1, Fulya Mordogan2
1Department of Analytical Chemistry, Faculty of Pharmacy, Ege University, Bornova, 35100, Izmir, Turkey; The Institute of Natural and Applied Sciences, Biotechnology Department, Ege University, Bornova, 35100, Izmir, Turkey.
Abstract:
Single nucleotide polymorphisms (SNPs) are important genetic changes related to many diseases such as breast cancer, Alzheimer's disease, and β-thalassemia. Because of the increased interest in biosensor technologies, there has been a notable surge in the creation of new techniques to identify these changes in recent years. These new methods are highly accurate and sensitive, cost-effective and fast, making them ideal for use in clinical analysis. The non-invasive nature of biosensing techniques further enhances their integration into clinical protocols and point-of-care diagnostics. Several electrochemical, optical, and mass-based biosensors are carefully examined in this extensive review; each is distinguished by unique sensing platforms and techniques. This review presents in-depth discussions of linear dynamic ranges, detection limits, and real-world applications of contemporary research in the diagnosis of biological substrate disorders.
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