Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

3.2K
A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
3.2K
Introduction to Nuclear Reprogramming01:14

Introduction to Nuclear Reprogramming

1.9K
Nuclear reprogramming is the process of switching gene expression of one cell type to that of another cell type, usually from a differentiated cell state to an undifferentiated cell state. Differentiation occurs during processes such as development and morphogenesis, tissue regeneration, and malignancy. Cells can also be artificially induced to reprogram their gene expression by techniques such as nuclear transfer, induced pluripotency, and cell fusion. Such techniques have many applications in...
1.9K
Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

2.2K
Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
2.2K
iPS Cell Differentiation01:22

iPS Cell Differentiation

2.6K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
2.6K
Forced Transdifferentiation01:28

Forced Transdifferentiation

1.8K
Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial...
1.8K
Cellular Differentiation00:57

Cellular Differentiation

2.5K
How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
2.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sea Cucumber <i>Holothuria glaberrima</i> High-Quality Genome: new and extended gene families in Holothuroidea.

Research square·2026
Same author

More extraordinary model systems for regeneration.

Development (Cambridge, England)·2025
Same author

Echinoderm Radial Glia-Like Cells Express Vertebrate Glial Markers.

The Journal of comparative neurology·2025
Same author

Intestinal microbiome profile of the brown rock sea cucumber (<i>Holothuria glaberrima</i>) using ITS and 16S rDNA amplicons from direct mechanical, enzymatic, and chemical metagenomic extraction.

Microbiology resource announcements·2025
Same author

Single-cell RNA sequencing of the holothurian regenerating intestine reveals the pluripotency of the coelomic epithelium.

eLife·2025
Same author

Critical Overview of Current Drug Abuse in Puerto Rico based on Governmental Data.

Puerto Rico health sciences journal·2024

Related Experiment Video

Updated: May 5, 2026

Differentiation of the SH-SY5Y Human Neuroblastoma Cell Line
08:07

Differentiation of the SH-SY5Y Human Neuroblastoma Cell Line

Published on: February 17, 2016

75.9K

Cellular dedifferentiation. Revisiting Betty Hay's legacy.

Alejandra Beltrán-Rivera1, José E García-Arrarás1

  • 1Biology Department, University of Puerto Rico, Rio Piedras, PR, USA.

Developmental Biology
|March 31, 2025
PubMed
Summary

Elizabeth Hay

Area of Science:

  • Regenerative Biology
  • Cellular Plasticity
  • Developmental Biology

Background:

  • The prevailing view held that differentiated cells were terminally specialized.
  • Previous research by C.S. Thornton laid groundwork for investigating cell fate.
  • Elizabeth Hay's work challenged established concepts of cell stability.

Purpose of the Study:

  • To investigate the potential for dedifferentiation in mature cells.
  • To explore the mechanisms underlying amphibian limb regeneration.
  • To re-evaluate the stability of the differentiated state in cells.

Main Methods:

  • Observation of amphibian limb regeneration.
  • Analysis of cellular transformations within the regeneration blastema.
  • Histological examination of cell types during regeneration.

More Related Videos

An Efficient Method to Obtain Dedifferentiated Fat Cells
06:11

An Efficient Method to Obtain Dedifferentiated Fat Cells

Published on: July 15, 2016

7.6K
De Novo Generation of Somatic Stem Cells by YAP/TAZ
13:05

De Novo Generation of Somatic Stem Cells by YAP/TAZ

Published on: May 7, 2018

11.3K

Related Experiment Videos

Last Updated: May 5, 2026

Differentiation of the SH-SY5Y Human Neuroblastoma Cell Line
08:07

Differentiation of the SH-SY5Y Human Neuroblastoma Cell Line

Published on: February 17, 2016

75.9K
An Efficient Method to Obtain Dedifferentiated Fat Cells
06:11

An Efficient Method to Obtain Dedifferentiated Fat Cells

Published on: July 15, 2016

7.6K
De Novo Generation of Somatic Stem Cells by YAP/TAZ
13:05

De Novo Generation of Somatic Stem Cells by YAP/TAZ

Published on: May 7, 2018

11.3K

Main Results:

  • Demonstrated that mature muscle cells can dedifferentiate.
  • Identified dedifferentiated cells transforming into progenitor cells.
  • Established the existence of cellular plasticity during regeneration.

Conclusions:

  • The differentiated state of cells is not always stable.
  • Cellular dedifferentiation is a key process in amphibian regeneration.
  • Hay's findings revolutionized understanding of cell plasticity and regenerative biology.