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Saline nasal irrigation for acute sinusitis (SNIFS II): a randomised controlled pilot trial with nested process
Roderick P Venekamp1, Ben Ainsworth2, Tammy Thomas3
1Department of General Practice and Nursing Science, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Background:
Despite having marginal beneficial effects, antibiotics are routinely prescribed in adults with acute sinusitis. Alternative interventions for this common condition are urgently needed.
Aim:
To assess the feasibility and acceptability of saline nasal irrigation for acute sinusitis.
Design & Setting:
Randomised controlled pilot trial with nested process evaluation in 24 English general practices between October 2019 and May 2021.
Method:
Participants were randomised to advice to high-volume hypertonic saline nasal irrigation with a delayed antibiotic prescription or usual care. Feasibility outcomes included recruitment and follow-up rates, adherence, and acceptability of the intervention.
Results:
Of those invited, n = 81/107 (76%) consented and were randomised (42 intervention, 39 usual care). Two participants were excluded owing to ineligibility. Antibiotic prescribing strategies were recorded at baseline for n = 79/79 (100%), with no or delayed antibiotics prescribed in 60% (n = 24/40) of the saline group versus 38% (n = 15/39) of the usual care group. At follow-up, 80% (n = 63/79) of participants recorded whether they consumed antibiotics or not. Among those from the intervention group who returned a symptom diary, 96% (n = 22/23) and 65% (n = 15/23) reported using saline nasal irrigation during the first and second week, respectively. Semi-structured interviews with 16 participants revealed that most were positive about trial participation and viewed saline nasal irrigation as acceptable, noting it as an alternative to antibiotics.
Conclusion:
Saline nasal irrigation is deemed acceptable for adults with acute sinusitis and a trial of such intervention is feasible. A large trial is warranted to assess the effectiveness of this intervention for this common condition.
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Etiology
Possible causes of this condition include high blood pressure, trauma, low humidity, upper respiratory tract infections, allergies, foreign bodies, nasal inhalation of corticosteroids or illicit drugs, excessive use of decongestant nasal sprays, facial or nasal surgery, anatomic malformation, tumors, or systemic...