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Updated: May 16, 2025

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
A hybrid approach with metaheuristic optimization and random forest in improving heart disease prediction
Geetha Narasimhan1, Akila Victor2
1School of Computer Science and Engineering, Vellore Institute of Technology, Vellore, Tamilnadu, India.
Insights
This study enhances cardiovascular disease prediction using machine learning and metaheuristic algorithms. Genetic Algorithm Optimized Random Forest (GAORF) achieved the highest accuracy, improving early heart disease diagnosis and reducing mortality rates.
Area of Science:
- Cardiology
- Artificial Intelligence
- Computational Biology
Background:
- Cardiovascular diseases (CVD) are a leading cause of global mortality, with current diagnostic methods in emergency settings achieving only 57% efficacy.
- Increasing costs and limitations in existing diagnostic practices necessitate improved methods for early heart disease prediction.
Purpose of the Study:
- To develop an intelligent machine learning (ML) model integrated with metaheuristic optimization for accurate CVD prediction.
- To enhance the accuracy of heart disease diagnosis, thereby aiming to reduce mortality rates.
Main Methods:
- Applied SelectKBest feature selection to the Cleveland Heart dataset.
- Evaluated metaheuristic optimization techniques including Genetic Algorithm Optimized Random Forest (GAORF), Particle Swarm Optimized Random Forest (PSORF), and Ant Colony Optimized Random Forest (ACORF).
- Compared classification algorithm performance before and after optimization, alongside SelectKBest filter methods.
Main Results:
- The Genetic Algorithm Optimized Random Forest (GAORF) demonstrated superior performance on the Cleveland Heart dataset.
- The proposed GAORF model achieved the highest accuracy compared to other optimization and classification techniques evaluated.
- Feature selection using SelectKBest provided an overall rank for dataset analysis.
Conclusions:
- Optimized machine learning models, particularly GAORF, significantly improve the accuracy of cardiovascular disease prediction.
- The integration of metaheuristic algorithms offers a promising approach to enhance diagnostic capabilities for heart disease.
- Early and accurate prediction of CVDs through advanced computational methods can contribute to reducing patient mortality.
Abstract:
Cardiovascular diseases (CVD) a major cause of morbidity and mortality among the world's non-communicable disease incidences. Though these practices are in use for diagnostics of different CVDs in clinical settings, need improvement because they are solving the purpose of only 57% of the patients in emergency. Due to this cost of diagnosis for heart disease is increasing which is the reason for analyzing heart disease and predicting it as early as possible. The main motive of this paper is to find an intelligent method for predicting disease effectively by means of machine learning (ML) and metaheuristic algorithms. Optimization techniques have the merit of handling non-linear complex problems. In this paper, an efficient ML model along with metaheuristic optimization techniques is evaluated for heart disease dataset to enhance the accuracy in predicting the disease. This will help to reduce the death rate due to the severity of heart disease. The SelectKBest feature selection is applied to the Cleveland Heart dataset and overall rank is obtained. Accuracy is measured. The optimization techniques namely Genetic Algorithm Optimized Random Forest (GAORF), Particle Swarm Optimized Random Forest (PSORF), and Ant Colony Optimized Random Forest (ACORF) are applied to the Cleveland dataset. Classification algorithms are performed before and after optimization. The output of the experiment explains that the GAORF performed better for the dataset considered. Also, a comparison is made along with the SelectKBest filter methods. The proposed model achieved better accuracy which is the maximum among other optimization and classification techniques.
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