Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hypersensitivities01:30

Hypersensitivities

426
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
426
Asthma-I: Introduction01:29

Asthma-I: Introduction

2.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.6K
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

106
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
106
Asthma-IV: Nursing Management01:30

Asthma-IV: Nursing Management

2.9K
The nursing management of asthma is a comprehensive approach that relies heavily on the expertise and dedication of healthcare professionals. It involves thorough assessment, accurate diagnosis, strategic planning, effective implementation, and diligent evaluation. By meticulously following this step-by-step process, healthcare professionals play a crucial role in providing the best possible care and treatment for patients with asthma, enhancing their overall health and well-being.
First, in...
2.9K
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

2.5K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.5K
Allergic Reactions02:06

Allergic Reactions

27.2K
Overview
27.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effectiveness of Baricitinib in Treating Atopic Dermatitis in Difficult-to-treat Areas: A Retrospective Real-world Study.

Acta dermato-venereologica·2026
Same author

Can Systemic Treatment for Childhood Psoriasis Be Stopped in Cases of Remission? Data From the ACMe Cohort.

Pediatric dermatology·2026
Same authorSame journal

Comparative Effectiveness and Safety of Baricitinib and Ritlecitinib in Severe Alopecia Areata: A Real-World Monocentric Retrospective Study.

Dermatology and therapy·2026
Same author

Early Response to Calcipotriol and Betamethasone Dipropionate PAD-Cream at Week 4 in Patients with Mild-to-Moderate Plaque Psoriasis: A Post-Hoc Pooled Analysis of Two Phase III Trials.

Dermatology and therapy·2026
Same author

Interpreting severity in atopic dermatitis: Refining severity bands using clinical trial data.

Journal of the European Academy of Dermatology and Venereology : JEADV·2026
Same author

Efficacy of Bimekizumab on Palmoplantar Psoriasis: A 16-Week Multicenter Retrospective Study-IL PSO (Italian Landscape PSOriasis).

Journal of clinical medicine·2026

Related Experiment Video

Updated: May 16, 2025

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
09:32

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Published on: September 26, 2019

7.1K

Risk Assessment in Atopic Dermatitis: Guidance from a Multidisciplinary Expert Panel.

Alessandra Narcisi1, Vito Di Lernia2, Maria Esposito3

  • 1Dermatology Unit, IRCCS Humanitas Research Hospital, Rozzano (MI), Italy.

Dermatology and Therapy
|March 31, 2025
PubMed
Summary

Janus kinase inhibitors (JAKi) are recommended for severe atopic dermatitis (AD). New safety guidelines restrict JAKi use, necessitating careful risk assessment for cardiovascular events, cancer, and blood clots. A structured approach aids dermatologists in managing patient risks.

Keywords:
Atopic dermatitisCancerJAKiMACERisk assessmentVTE

More Related Videos

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

2.1K
A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
08:02

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

3.1K

Related Experiment Videos

Last Updated: May 16, 2025

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
09:32

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Published on: September 26, 2019

7.1K
Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

2.1K
A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
08:02

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

3.1K

Area of Science:

  • Dermatology
  • Pharmacology
  • Risk Management

Background:

  • Severe atopic dermatitis (AD) treatment guidelines recommend Janus kinase inhibitors (JAKi).
  • Recent European Medicines Agency reviews led to updated JAKi safety profiles and restrictions, particularly for upadacitinib.
  • These changes necessitate careful risk assessment for major adverse cardiovascular events (MACE), cancer, and venous thromboembolism (VTE).

Purpose of the Study:

  • To provide dermatologists with a platform for multidisciplinary risk assessment regarding MACE, cancer, and VTE in patients undergoing JAKi therapy.
  • To characterize patient profiles and identify risk factors for MACE, cancer, and VTE.
  • To develop a clear framework and practical tools for risk assessment in AD management.

Main Methods:

  • An interdisciplinary workshop (Multiple In-treatment Risk Assessment & Management) involving cardiologists, oncologists, respiratory specialists, and hematologists.
  • Characterization of common and less common patient profiles for risk assessment.
  • Identification of risk factors for MACE, cancer, and VTE through expert collaboration.

Main Results:

  • A thorough medical history is fundamental for risk assessment in AD patients, irrespective of therapy.
  • Risk factors for MACE, cancer, and VTE were identified through interdisciplinary collaboration.
  • A proposed risk-level benchmarking system using general population data for AD patients was developed.

Conclusions:

  • A structured, multidisciplinary approach is crucial for assessing and managing risks associated with JAKi in severe AD.
  • The study provides a practical checklist to support routine clinical risk assessments.
  • This framework aims to improve the standard of care for patients with severe atopic dermatitis.