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Related Concept Videos

Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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Related Experiment Video

Updated: May 12, 2026

Delivery of Therapeutic siRNA to the CNS Using Cationic and Anionic Liposomes
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Peptide-functionalized nanoparticles for brain-targeted therapeutics.

Sophia Tang1, Emily L Han1, Michael J Mitchell2,3,4,5,6,7,8

  • 1Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, 19104, USA.

Drug Delivery and Translational Research
|March 31, 2025
PubMed
Summary

Peptide-functionalized nanoparticles show promise for delivering drugs to the brain by overcoming biological barriers. Advanced peptide design, including AI, enhances brain targeting for neurological disease treatments.

Keywords:
Blood–Brain BarrierDrug DeliveryNanoparticlesPeptides

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Neuroscience

Background:

  • Intravenous drug delivery to the brain faces significant challenges due to biological barriers like the blood-brain barrier (BBB).
  • Nanoparticle (NP)-based systems require selective brain targeting to avoid off-target accumulation and achieve therapeutic efficacy.
  • Peptides are emerging as effective brain-targeting ligands for NPs due to their favorable properties.

Purpose of the Study:

  • To review the design and application of peptide-functionalized NP systems for neurological diseases.
  • To explore advanced peptide design strategies for enhanced brain targeting.
  • To highlight the potential of computational methods like deep learning in designing novel brain-penetrant peptides.

Main Methods:

  • Review of current literature on peptide-functionalized NPs for brain delivery.
  • Analysis of peptide design strategies, including modifications for improved properties.
  • Exploration of generative deep-learning models for *in silico* peptide design.

Main Results:

  • Peptide conjugation to NPs enables receptor-specific targeting and BBB penetration.
  • Diverse peptide design strategies enhance membrane permeability and multi-receptor engagement.
  • Computational approaches offer novel avenues for designing highly effective brain-targeting peptides.

Conclusions:

  • Peptide-functionalized NPs represent a viable strategy for targeted brain drug delivery in neurological disorders.
  • Rational peptide design and AI-driven approaches are crucial for optimizing NP performance.
  • Further development in this area holds significant potential for treating brain diseases.