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Optimizing IVIg in Xenotransplantation: A Call to Action

Robin K Avery1, Olivia S Kates1, Kapil K Saharia2

  • 1Division of Infectious Diseases, Department of Medicine, Johns Hopkins University, Baltimore, MD.

Transplantation
|April 1, 2025
PubMed
Summary

No abstract available in PubMed .

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Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...