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Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...

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Related Experiment Video

Updated: May 16, 2025

Mechanical Stimulation of Stem Cells Using Cyclic Uniaxial Strain

Mechanical Stimulation of Stem Cells Using Cyclic Uniaxial Strain

Published on: July 29, 2007

Cellular mechanical memory: a potential tool for mesenchymal stem cell-based therapy.

Sanjay Kumar Kureel¹, Rosario Maroto², Kristen Davis²

¹Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, 77555, USA. skkureel113@gmail.com.

Stem Cell Research & Therapy

|April 1, 2025

Summary

This summary is machine-generated.

Mechanical forces significantly influence cell behavior and function. Cellular mechanical memory (CMM) in mesenchymal stem cells (MSCs) offers a promising target for cell-based therapies and disease research.

Keywords:

Cell-based therapy Fibrosis Mechanical memory Mechanical stimuli Mesenchymal stem cells (MSCs)Senescence

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Last Updated: May 16, 2025

Mechanical Stimulation of Stem Cells Using Cyclic Uniaxial Strain

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Published on: July 29, 2007

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Published on: January 18, 2019

Area of Science:

Biomedical Engineering
Cell Biology
Mechanobiology

Background:

Mechanical properties like stiffness and fluid flow influence cellular functions, impacting tissue characteristics and cell phenotypes.
Cells respond to mechanical stimuli by sensing forces, altering shape, and adapting functions, a process crucial for tissue homeostasis.
Mechanical triggers can induce a 'memory' in cells, affecting their plasticity and adaptation.

Purpose of the Study:

To review the role of cellular mechanical memory (CMM) in cells of the mesodermal lineage.
To explore CMM as a potential therapeutic target for cell-based therapy (CBT).
To highlight the implications of CMM in cancer research, fibrosis, and senescence.

Main Methods:

Literature review focusing on mechanobiology and cellular responses to mechanical stimuli.
Analysis of studies investigating cellular mechanical memory (CMM) in mesenchymal stem cells (MSCs), fibroblasts, and chondrocytes.
Synthesis of findings related to the impact of mechanical factors on cell phenotype and ECM remodeling.

Main Results:

Mechanical forces, including stiffness, flow, loading, compression, and stretching, demonstrably affect cell functions and phenotypes.
Cellular responses to mechanical changes can lead to ECM alterations, increasing tissue stiffness and influencing function.
Cellular mechanical memory (CMM) is a key feature enabling cells to adapt and retain responses to mechanical stimuli.

Conclusions:

Cellular mechanical memory (CMM) is a critical cellular adaptation to mechanical cues, particularly evident in mesenchymal stem cells (MSCs).
Targeting CMM presents a novel strategy to address challenges in cell-based therapy (CBT), such as cell scarcity.
Understanding CMM is vital for advancing research in cancer, fibrosis, and senescence, offering potential therapeutic avenues.