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The Complex Interplay of Irisin Levels, Low Birth Weight, and Blood Pressure in Prepubescent Children

Raissa Munhão Serra1,2, Franciele De Meneck1, Fernanda Thomazini1

  • 1Program of Translational Medicine, School of Medicine, Federal University of São Paulo, São Paulo, Brazil.

American Journal of Human Biology : the Official Journal of the Human Biology Council
|April 1, 2025
PubMed

Insights

Low birth weight in children is linked to lower irisin levels and higher blood pressure. Irisin may play a complex role in cardiovascular health, especially in those with low birth weight.

Area of Science:

  • Endocrinology
  • Cardiovascular Research
  • Pediatric Health

Background:

  • Irisin is a hormone involved in metabolic, inflammatory, and oxidative stress processes.
  • Irisin is a potential target for managing cardiovascular diseases.
  • This study investigated plasma irisin levels in prepubertal children.

Purpose of the Study:

  • To evaluate plasma irisin levels in prepubertal children.
  • To examine the relationship between irisin and birth weight, anthropometry, biochemical profile, and blood pressure.
  • To understand the role of irisin in cardiometabolic programming.

Main Methods:

  • Cross-sectional study of 136 prepubertal children (ages 6-11).
  • Assessed anthropometric parameters, blood pressure, and biochemical profiles.
  • Included 27.9% of participants born at low birth weight.

Main Results:

  • Low birth weight children had significantly lower irisin levels (p < 0.001).
  • Birth weight negatively correlated with blood pressure and positively with irisin.
  • Irisin levels positively associated with systolic blood pressure, even after adjustments.

Conclusions:

  • A complex interplay exists between birth weight, irisin, and cardiovascular regulation in children.
  • Low birth weight and high plasma irisin are predictive of elevated blood pressure.
  • Irisin may have dual roles in different tissues and compensatory mechanisms.
Abstract

Keywords:
birth weightchildrenirisinsystolic blood pressure

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