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Updated: May 16, 2025

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors
Published on: February 27, 2015
Sex Differences in the Cancer Proteome
Chenghao Zhu1,2,3,4,5, Nicole Zeltser1,2,3,4,5, Jieun Oh1,2,3,4,5
1Department of Human Genetics, University of California, Los Angeles, CA, USA.
Sex has a modest impact on the cancer proteome, with differences observed in lung, liver, kidney, and pancreas cancers. Current proteomics data has limited power to detect these sex-specific protein variations.
Area of Science:
- Oncology
- Proteomics
- Genomics
Background:
- Proteins are crucial in cancer biology, serving as drug targets and biomarkers.
- Sex influences disease proteomes, including cancer incidence, progression, and treatment response.
- The impact of sex on the cancer proteome is not well understood.
Purpose of the Study:
- To quantify sex differences in proteomes across eight cancer types.
- To identify specific genes with sex-differential protein abundance in cancer.
Main Methods:
- Analysis of 1,590 proteomes from eight cancer types.
- Identification of genes with sex-differential protein abundance.
- Pathway analysis of identified sex-differential proteins.
Main Results:
- Identified 39 genes with sex-differential protein abundance in lung adenocarcinoma.
- Identified 15 genes in hepatocellular carcinoma, kidney, and pancreas cancers.
- Found that a subset of protein differences linked to sex-differential copy number aberrations.
- Observed enrichment of sex-differential proteins in MYC and E2F target pathways in lung adenocarcinoma.
Conclusions:
- Sex has a modest impact on the cancer proteome.
- Existing proteomics cohorts have limited power for detecting sex differences.
- Further research with larger cohorts is needed to fully elucidate sex's role in cancer proteomics.
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