Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

DNA Replication02:40

DNA Replication

48.0K
DNA replication involves the separation of the two strands of the double helix, with each strand serving as a template from which the new complementary strand is copied.  After replication, each double-stranded DNA includes one parental or “old” strand and one “new” strand. This is known as semiconservative replication. The resulting DNA molecules have the same sequence and are divided equally into the two daughter cells.
Replication in Prokaryotes
DNA replication...
48.0K
The DNA Replication Fork01:02

The DNA Replication Fork

35.3K
An organism’s genome needs to be duplicated in an efficient and error-free manner for its growth and survival. The replication fork is a Y-shaped active region where two strands of DNA are separated and replicated continuously. The coupling of DNA unzipping and complementary strand synthesis is a characteristic feature of a replication fork.   Organisms with small circular DNA, such as E. coli, often have a single origin of replication; therefore, they have only two replication...
35.3K
The Replisome03:01

The Replisome

32.7K
DNA replication is carried out by a large complex of proteins that act in a coordinated matter to achieve high-fidelity DNA replication. Together this complex is known as the DNA replication machinery or the replisome.
The synthesis of the leading and lagging strands is a highly coordinated process. To explain this, the “Trombone model” was proposed by Bruce Alberts in 1980. The DNA loop formation starts when a primer is synthesized on the parent lagging strand. The loop grows with...
32.7K
Restarting Stalled Replication Forks02:37

Restarting Stalled Replication Forks

5.7K
DNA replication is initiated at sites containing predefined DNA sequences known as origins of replication. DNA is unwound at these sites by the minichromosome maintenance (MCM) helicase and other factors such as Cdc45 and the associated GINS complex.The unwound single strands are protected by replication protein A (RPA) until DNA polymerase starts synthesizing DNA at the 5’ end of the strand in the same direction as the replication fork. To prevent the replication fork from falling apart,...
5.7K
Replication in Prokaryotes01:32

Replication in Prokaryotes

23.9K
DNA replication has three main steps: initiation, elongation, and termination. Replication in prokaryotes begins when initiator proteins bind to the single origin of replication (ori) on the cell's circular chromosome. Replication then proceeds around the entire circle of the chromosome in each direction from the two replication forks, resulting in two DNA molecules.
Many Proteins Work Together to Replicate the Chromosome
Replication is coordinated and carried out by a host of specialized...
23.9K
Replication in Eukaryotes01:29

Replication in Eukaryotes

12.8K
In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
12.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Limited sensory horizons could just as well make conscious perception more likely, rather than less likely.

The Behavioral and brain sciences·2026
Same author

Object and setting identification in natural auditory scenesa).

The Journal of the Acoustical Society of America·2026
Same author

Musical groove listening does not enhance primary motor cortex activation.

Imaging neuroscience (Cambridge, Mass.)·2026
Same author

Investigating the replicability of the social and behavioural sciences.

Nature·2026
Same author

Adversarial collaborations: all theories must be subject to critical evaluation.

Nature·2025
Same author

What makes a theory of consciousness unscientific?

Nature neuroscience·2025
Same journal

Whole-Embryo 3D Quantification Reveals Conserved Topological Design and Scaling of Germ Layers in Xenopus.

bioRxiv : the preprint server for biology·2026
Same journal

scRNA-seq and genomics analyses reveal key mechanisms of inverted papilloma-associated sinonasal squamous cell carcinoma malignant transformation.

bioRxiv : the preprint server for biology·2026
Same journal

M1C IS NECESSARY FOR DARAXONRASIB RESISTANCE OF NSCLC KRAS(G12C) MUTANT CELLS.

bioRxiv : the preprint server for biology·2026
Same journal

A human-specific genetic modifier reconfigures large-scale cortical network dynamics underlying behavioral performance.

bioRxiv : the preprint server for biology·2026
Same journal

<i>Staphylococcus aureus</i> uses a eukaryotic-like uridyltransferase to make UDP-GlcNAc for cell wall synthesis.

bioRxiv : the preprint server for biology·2026
Same journal

Dynamic redistribution of eIF4F controls cap-dependent translation initiation.

bioRxiv : the preprint server for biology·2026
See all related articles

Related Experiment Video

Updated: Jun 16, 2026

Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase
07:27

Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase

Published on: April 29, 2010

Registered Report: Replication and Extension of.

Karli M Nave, Erin E Hannon, Joel S Snyder

    Biorxiv : the Preprint Server for Biology
    |April 1, 2025
    PubMed
    Summary
    This summary is machine-generated.

    Replication studies found smaller neural effects for imagining musical beat than previously reported. This suggests large sample sizes are needed to reliably detect beat perception using frequency tagging.

    Keywords:
    auditory neurosciencebeat and meter perceptionfrequency taggingmultilabmusic cognitionpreregistrationreplication

    More Related Videos

    Massively Parallel Reporter Assays in Cultured Mammalian Cells
    11:03

    Massively Parallel Reporter Assays in Cultured Mammalian Cells

    Published on: August 17, 2014

    G2-seq: A High Throughput Sequencing-based Technique for Identifying Late Replicating Regions of the Genome
    06:40

    G2-seq: A High Throughput Sequencing-based Technique for Identifying Late Replicating Regions of the Genome

    Published on: March 22, 2018

    Related Experiment Videos

    Last Updated: Jun 16, 2026

    Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase
    07:27

    Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase

    Published on: April 29, 2010

    Massively Parallel Reporter Assays in Cultured Mammalian Cells
    11:03

    Massively Parallel Reporter Assays in Cultured Mammalian Cells

    Published on: August 17, 2014

    G2-seq: A High Throughput Sequencing-based Technique for Identifying Late Replicating Regions of the Genome
    06:40

    G2-seq: A High Throughput Sequencing-based Technique for Identifying Late Replicating Regions of the Genome

    Published on: March 22, 2018

    Area of Science:

    • Cognitive Neuroscience
    • Auditory Perception
    • Neuroscience of Music

    Background:

    • Distinguishing stimulus-driven from conscious processing of neural activity is a long-standing challenge.
    • Previous research on neural processing of musical beat perception may be confounded by stimulus-driven activity.
    • Frequency tagging offered a method to isolate neural correlates of beat perception by measuring brain activity at specific frequencies.

    Purpose of the Study:

    • To conduct 13 independent conceptual replications of Nozaradan et al. (2011) to verify findings on neural processing of imagined musical beat.
    • To investigate whether the observed neural effects are repeatable and influenced by music or dance training.
    • To assess the reliability of frequency tagging for studying the neural basis of conscious beat perception.

    Main Methods:

    • Employed a registered report protocol with 13 independent replications of a frequency tagging study.
    • Participants performed auditory imagery tasks while listening to isochronous stimuli.
    • Incorporated behavioral tasks to measure conscious perception and analyzed neural activity using meta-analyses and logistic regression.

    Main Results:

    • Replication studies yielded significantly smaller effect sizes for neural activity related to imagined beat compared to the original study.
    • Music and dance training did not moderate the observed neural effects.
    • Only neural activity at the stimulus frequency, not the imagery-related frequency, predicted task performance, challenging the original study's interpretation.

    Conclusions:

    • The findings suggest that frequency tagging may require very large sample sizes to reliably detect neural correlates of beat perception.
    • The results question the robustness of previous findings and the utility of frequency tagging for studying conscious beat perception.
    • Discrepancies highlight the need for rigorous replication in cognitive neuroscience and refining methods for studying perceptual awareness.