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Related Concept Videos

Herniated Intervertebral Disc l: Introduction01:29

Herniated Intervertebral Disc l: Introduction

44
Intervertebral disc herniation refers to the displacement of the nucleus pulposus (the gel-like inner core of the disc) through a tear or weakened area in the annulus fibrosus (the outer fibrous ring). The displaced disc material extends beyond the normal boundaries of the disc space and may compress or irritate nearby spinal nerve roots or, less commonly, the spinal cord.Etiology and Risk FactorsHerniation commonly results from degeneration, in which aging reduces disc hydration and...
44
Degenerative Disc Disease I: Introduction01:27

Degenerative Disc Disease I: Introduction

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Degenerative disc disease is a chronic condition in which intervertebral discs gradually lose structure and function. It is not infectious or autoimmune; rather, it results from age-related biochemical and mechanical changes, influenced by genetic, metabolic, and environmental factors.Structure and Function of DiscsThe spine contains 23 intervertebral discs that absorb load, distribute forces, maintain spacing, and allow flexibility. Each disc consists of a nucleus pulposus, a gel-like core...
29
Degenerative Disc Disease ll: Pathophysiology01:23

Degenerative Disc Disease ll: Pathophysiology

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The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...
34

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An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
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Self-healing injectable multifunctional hydrogels for intervertebral disc disease.

Zhengrong Gu1, Yi He2, Honglin Xiang3

  • 1Department of Orthopedics, Affiliated Guang'an District People's Hospital of North Sichuan Medical College, Guang'an County, 638000, PR China.

Materials Today. Bio
|April 1, 2025
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Summary

Injectable hydrogels offer a promising minimally invasive treatment for intervertebral disc degeneration (IVDD). These self-healing materials mimic the disc’s natural environment, enabling targeted delivery for tissue regeneration.

Keywords:
BioinformaticsHydrogelsInjectableIntervertebral disc degenerationSelf-healing

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Orthopedics

Background:

  • Intervertebral disc degeneration (IVDD) is a growing health concern, particularly in aging populations.
  • Limited vascularization of intervertebral discs hinders conventional systemic treatments.
  • Localized injection therapies are emerging as effective strategies for IVDD management.

Purpose of the Study:

  • To review the anatomy, pathophysiology, and limitations of current IVDD treatments.
  • To explore research trends and hotspots in injectable hydrogel applications for IVDD via bibliometric analysis.
  • To discuss the potential of injectable hydrogels in drug delivery, tissue engineering, and regenerative medicine for IVDD.

Main Methods:

  • Bibliometric analysis of research trends in injectable hydrogels for IVDD.
  • Discussion of hydrogel construction mechanisms (physical, chemical, biological crosslinking).
  • Review of biomaterial selection and fabrication methods for IVD tissue engineering.

Main Results:

  • Injectable hydrogels show potential for minimally invasive delivery and targeted therapeutic release.
  • Hydrogels can replicate the native nucleus pulposus mechanical environment.
  • Bibliometric analysis reveals key research areas and future directions in hydrogel-based IVDD treatment.

Conclusions:

  • Self-healing injectable hydrogels represent a promising biomaterial for treating IVDD.
  • Their tunable properties and biomimetic characteristics support drug, cell, and gene delivery for IVD regeneration.
  • Further research into novel hydrogels and fabrication methods is crucial for advancing IVD tissue engineering.