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Updated: May 16, 2025

Non-invasive Skeletal Muscle Quantification in Small Animals Using Micro-computed Tomography
Published on: November 8, 2024
Muscle Function, Muscle Disease, and Positron Emission Tomography-Computed Tomography: A Narrative Review
Shinji Yamamoto1, Yukinori Okada2
1Department of Radiological Technology, Japan Community Healthcare Organization (JCHO) Tokyo Yamate Medical Center, Tokyo, JPN.
Abstract:
18F-fluorodeoxyglucose (18F-FDG) is a radiopharmaceutical that exhibits glucose-like kinetics and is used in positron emission tomography (PET). 18F-FDG is used for cancer diagnosis in clinical practice. However, 18F-FDG uptake is also observed in normal organs, such as the brain, liver, and heart, with high glucose consumption. Moreover, 18F-FDG uptake is also observed in muscles, where its accumulation and radioactivity reflect muscle activity. Dystonia is characterized by excessive muscle movement. Recently, 18F-FDG and technetium-99m-methoxyisobutyl isocyanide ([99mTc]MIBI) have been used for the diagnosis and botulinum toxin therapy evaluation of dystonia. This review aimed to summarize the utility of 18F-FDG-PET for the evaluation of muscle activity and diagnosis of muscle diseases such as dystonia, polymyositis, dermatomyositis, and polymyalgia rheumatica.
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