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Updated: May 12, 2026

Monitoring Tumor Metastases and Osteolytic Lesions with Bioluminescence and Micro CT Imaging
Published on: April 14, 2011
Osteolytic Lesions: An Unexpected Diagnosis
Pedro Mesquita1, Diogo Ferreira da Silva1, Sofia Mateus1
1Internal Medicine, Unidade Local de Saúde de São José, Hospital de Santo António dos Capuchos, Lisboa, PRT.
Abstract:
This is the case of a patient who went to the emergency department with back pain and constitutional symptoms (weight loss, anorexia, nausea) lasting one month. Blood tests revealed hypercalcemia and new-onset kidney failure that prompted admission for study. Bone X-ray revealed multiple lytic lesions, and myeloma screening was negative. After a bone marrow biopsy guided by ultrasound of one lesion, it was possible to obtain the diagnosis of diffuse large B-cell lymphoma. We present this case for the diagnostic challenge and atypical presentation simulating multiple myeloma with hypercalcemia.
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