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Humoral Immunity Against Orthopoxvirus in Vaccinated and Unvaccinated Individuals during 2022 Mpox Outbreak
Yijia Li1, Michael B Townsend2, Shanshan Li2
1School of Medicine, University of Pittsburgh, Pittsburgh, PA.
Medrxiv : the Preprint Server for Health Sciences
|April 1, 2025
Abstract:
Little is known about serological responses to MVA-BN (JYNNEOS) against mpox in elderly individuals with or without HIV. In this study, MVA-BN induced sustained IgG levels regardless of HIV status even up to one year. Birth before 1973 correlated with higher IgG. MVA-BN unvaccinated individuals with HIV had lower IgG than vaccinated.
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