Related Experiment Video
Updated: May 16, 2025
10:32
Mitochondria-associated ER Membranes MAMs and Glycosphingolipid Enriched Microdomains GEMs: Isolation from Mouse Brain
Published on: March 4, 2013
24.3K
Mitochondria associated membranes in dilated cardiomyopathy: connecting pathogenesis and cellular dysfunction
Pingge He1, Hongbo Chang1, Yueqing Qiu1
1Second School of Clinical Medicine, Henan University of Chinese Medicine, Zhengzhou, China.
Frontiers in Cardiovascular Medicine
|April 1, 2025
Summary
Mitochondria-associated membranes (MAMs) are crucial for heart health. Disruptions in MAMs contribute to dilated cardiomyopathy (DCM) and may offer new therapeutic targets.
Area of Science:
- Cardiovascular Biology
- Cellular Biology
- Mitochondrial Research
Background:
- Dilated cardiomyopathy (DCM) is a primary cause of heart failure with limited treatment options.
- Research traditionally focused on energy deficits and calcium issues in DCM.
- Mitochondria-associated membranes (MAMs) are emerging as critical players in cardiac function.
Purpose of the Study:
- To review the role of MAMs in cellular processes relevant to cardiac health.
- To explore how MAM dysfunction contributes to DCM pathogenesis.
- To highlight MAMs as potential targets for novel DCM therapies.
Main Methods:
- This is a narrative review.
- Key literature on MAMs, endoplasmic reticulum (ER)-mitochondria interfaces, and DCM was synthesized.
- Cellular processes regulated by MAMs were examined.
Main Results:
- MAMs regulate vital cellular functions including calcium homeostasis, lipid metabolism, and mitochondrial dynamics.
- MAM dysfunction can trigger ER stress, inflammation, and cell death, destabilizing cellular homeostasis.
- These disruptions are linked to the progression of DCM.
Conclusions:
- MAMs are critical regulators of cardiac homeostasis.
- Dysfunctional MAMs are implicated in the pathophysiology of DCM.
- Targeting MAMs may offer novel diagnostic and therapeutic strategies for DCM.
Related Concept Videos
01:45Mitochondrial Membranes
6.6K
A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
6.6K
01:28The Inner Mitochondrial Membrane
3.2K
The inner mitochondrial membrane is the primary site of ATP synthesis. The inner membrane domain that forms a smooth layer adjacent to the outer membrane is called the inner boundary membrane. This domain contains membrane transporters that drive metabolites in and out of the mitochondria. In contrast, the inner membrane network that invaginates into the matrix space is called the cristae membrane. This domain accounts for principle mitochondrial function as it accommodates the protein...
3.2K
01:37Mitochondria
8.9K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
8.9K
01:19Translocation of Proteins into the Mitochondria
3.0K
Mitochondrial precursors are translocated to the internal subcompartments via independent mechanisms involving distinct protein machineries called translocases.
Sorting of outer membrane proteins:
Mitochondrial outer membrane proteins are of two types: the transmembrane, beta-barrel porins, and the membrane-anchored, alpha-helical proteins. Beta-barrel porin precursors are translocated by the TOM complex and inserted into the outer mitochondrial membrane by the SAM complex. In contrast,...
Sorting of outer membrane proteins:
Mitochondrial outer membrane proteins are of two types: the transmembrane, beta-barrel porins, and the membrane-anchored, alpha-helical proteins. Beta-barrel porin precursors are translocated by the TOM complex and inserted into the outer mitochondrial membrane by the SAM complex. In contrast,...
3.0K
01:32Chemiosmosis
96.4K
Oxidative phosphorylation is a highly efficient process that generates large amounts of adenosine triphosphate (ATP), the basic unit of energy that drives many cellular processes. Oxidative phosphorylation involves two processes— the electron transport chain and chemiosmosis.
Electron Transport Chain
The electron transport chain involves a series of protein complexes on the inner mitochondrial membrane that undergo a series of redox reactions. At the end of this chain, the electrons...
Electron Transport Chain
The electron transport chain involves a series of protein complexes on the inner mitochondrial membrane that undergo a series of redox reactions. At the end of this chain, the electrons...
96.4K
01:41The Supercomplexes in the Crista Membrane
2.5K
The mitochondrial cristae membrane is the primary site for the oxidative phosphorylation (OXPHOS) process of energy conversion mediated through respiratory complexes I to V. These complexes have been widely studied for decades, and it has been proven that they form supramolecular structures called respiratory supercomplexes (SC). These higher-order complexes may be crucial in maintaining the biochemical structure and improving the physiological activity of the individual complexes while...
2.5K