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Updated: May 16, 2025

A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9
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A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9

Published on: August 28, 2018

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PCSK9 Manipulates Lipid Metabolism and the Immune Microenvironment in Cancer

Chaochu Cui1, Aiwei Yan1, Shengming Huang1,2

  • 1Henan Key Laboratory of Medical Tissue Regeneration, Xinxiang Medical University, Xinxiang, Henan, People's Republic of China.

Oncotargets and Therapy
|April 1, 2025
PubMed

Insights

Proprotein convertase subtilisin/kexin type 9 (PCSK9) influences cancer progression and immune evasion by regulating lipid metabolism and immune cell function. Understanding PCSK9

Area of Science:

  • Oncology
  • Immunology
  • Metabolic research

Background:

  • Cancer is a leading global cause of death, with immunotherapy showing significant promise.
  • Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key regulator of plasma lipid levels.
  • Emerging evidence highlights PCSK9's role in cancer biology and immune modulation.

Purpose of the Study:

  • To comprehensively review the multifaceted roles of PCSK9 in cancer.
  • To elucidate the mechanisms by which PCSK9 influences tumorigenesis, progression, immune escape, and drug resistance.
  • To highlight PCSK9 as a potential therapeutic target in oncology.

Main Methods:

  • Literature review of preclinical and clinical studies on PCSK9 in cancer.
  • Analysis of PCSK9's impact on lipid metabolism and immune cell signaling pathways.
  • Synthesis of current knowledge on PCSK9's involvement in tumor development and treatment resistance.

Main Results:

  • PCSK9 modulates immune responses during tumor progression via lipid metabolism.
  • PCSK9 influences the fate and function of various immune cells (e.g., inflammatory, MHC, TCR signaling).
  • PCSK9 is implicated in cancer immune escape and acquired drug resistance.

Conclusions:

  • PCSK9 plays a significant, previously underappreciated role in cancer immunity and progression.
  • Targeting PCSK9 may offer novel strategies to enhance cancer immunotherapy and overcome resistance.
  • Further research into PCSK9's immunomodulatory functions is warranted for clinical translation.
Keywords:
PCSK9cancerimmunotherapylipid metabolism

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