STAT3 Signaling Pathway in Health and Disease
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Signal transducer and activator of transcription 3 (STAT3) is crucial for health but drives diseases like cancer when overactive. This review explores STAT3
Area Of Science
- Molecular Biology
- Cell Signaling
- Oncology
Background
- Signal transducer and activator of transcription 3 (STAT3) is a key transcription factor regulating homeostasis.
- Dysregulated STAT3 signaling is implicated in cancer, autoimmune disorders, inflammation, and neurodegenerative diseases.
- The IL-6/JAK/STAT3 pathway is central to STAT3 activation, impacting tumor progression and therapy resistance.
Purpose Of The Study
- To provide a comprehensive review of STAT3's role in health and disease.
- To evaluate current and emerging therapeutic strategies targeting STAT3.
- To identify knowledge gaps and future directions for STAT3-targeted therapies.
Main Methods
- Systematic literature review of STAT3 signaling pathways and therapeutic interventions.
- Analysis of STAT3's involvement in disease pathogenesis, including cancer stem cell maintenance, metastasis, and inflammation.
- Evaluation of various therapeutic strategies such as JAK inhibitors, STAT3 inhibitors, antisense oligonucleotides, and nanomedicine.
Main Results
- Persistent STAT3 activation contributes to various pathologies, especially cancer.
- Existing therapeutic strategies show promise but face challenges in specificity and efficacy.
- Emerging approaches like nanomedicine offer improved delivery and reduced toxicity.
Conclusions
- STAT3 is a critical therapeutic target for numerous diseases.
- Further research into STAT3 signaling crosstalk, epigenetic regulation, and resistance mechanisms is needed.
- Development of next-generation STAT3 inhibitors holds significant translational potential for improved clinical outcomes.
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
Related Concept Videos
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a...
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...