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Updated: May 16, 2025

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
Published on: August 12, 2020
Factors associated with elevated gentamicin trough levels in neonates: a retrospective analysis of dosing and
Julian Trah1,2, Philipp Deindl1, Alexandra Luister1
1Department of Neonatology and Pediatric Intensive Care Medicine, University Children's Hospital, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Objective:
Investigate determinants of elevated gentamicin trough levels in neonates.
Methods:
This single-center retrospective analysis used a multivariate linear regression model to explore the relationship between gentamicin trough concentrations and factors such as creatinine levels, dosage, day of life, sex, CRP levels, and dosing interval in neonates.
Results:
In 215 neonates, including 68 (31.6%) premature neonates with a postmenstrual age of ≤35 weeks, shorter dosing intervals, higher creatinine levels, and increased dosage were linked to higher gentamicin trough levels. Elevated CRP levels corresponded with lower trough levels.
Conclusion:
This study highlights the critical role of dosing frequency, kidney function, and inflammatory status in influencing gentamicin trough levels in neonates. However, all gentamicin trough levels were within the 2 µg/ml threshold.
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