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Cerebral pilocytic astrocytoma.

G B Clark, J M Henry, P E McKeever

    Cancer
    |September 1, 1985
    PubMed
    Summary

    Cerebral pilocytic astrocytoma, a type of brain tumor, generally shows low-grade characteristics. Despite potential challenges like location, these tumors typically follow a slow-growing course with good survival rates post-surgery.

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    Area of Science:

    • Neuro-oncology
    • Pathology

    Background:

    • Cerebral pilocytic astrocytoma is an intracranial tumor with incompletely understood biological features.
    • Limited documentation exists regarding the specific biological characteristics of this tumor type.

    Purpose of the Study:

    • To correlate the histological appearance of cerebral pilocytic astrocytoma with clinical characteristics.
    • To document the biological behavior and prognosis of cerebral pilocytic astrocytoma.

    Main Methods:

    • Retrospective analysis of 30 patient cases of cerebral pilocytic astrocytoma.
    • Histological examination of tumor samples.
    • Correlation of tumor histology with clinical data, including age of onset, symptom duration, and survival.

    Main Results:

    • The mean age of onset was 22.15 years, with a mean preoperative symptom duration of 3.77 years.
    • Mean postoperative survival was 5.91 years, with 87% of patients surviving surgery.
    • Histologic features were consistent with a low-grade tumor, despite some cases having guarded prognoses due to location or infiltration.

    Conclusions:

    • Cerebral pilocytic astrocytoma generally exhibits characteristics of a low-grade neoplasm.
    • The tumor's natural course is typically that of a relatively low-grade tumor, with a favorable prognosis for most patients.

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