Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Microbial Corrosion01:24

Microbial Corrosion

93
Microbiologically Influenced Corrosion (MIC) is a significant form of material degradation caused by the metabolic activities of microorganisms. This phenomenon poses substantial challenges across various industries, including oil and gas, maritime, and water treatment sectors.MIC occurs when microorganisms, such as bacteria, archaea, and fungi, colonize metal surfaces, forming biofilms that alter the local electrochemical environment. These biofilms can lead to the production of corrosive...
93
Probiotics01:22

Probiotics

296
Probiotics are live, non-pathogenic microorganisms that confer health benefits by modulating the gut microbiota. The human gastrointestinal tract harbors a complex microbial ecosystem, and the balance of this microbiota is crucial for digestive and systemic health. Among the most extensively studied and utilized probiotics are species formerly classified within the genera Lactobacillus and Bifidobacterium. These organisms not only naturally colonize the human gut but are also consumed through...
296
Bioplastics01:27

Bioplastics

70
Bioplastics derived from microbial processes present a sustainable alternative to conventional petroleum-based plastics. Among these, polyhydroxyalkanoates (PHAs), particularly polyhydroxybutyrates (PHBs), have emerged as prominent candidates due to their biodegradability and biocompatibility. These polymers are synthesized by a variety of bacteria, such as Cupriavidus necator and Pseudomonas putida, which naturally accumulate PHAs as intracellular carbon and energy reserves, especially under...
70
Microbial Bioremediation of Plastics01:28

Microbial Bioremediation of Plastics

131
Polyethylene terephthalate (PET) is a synthetic polymer widely utilized in the packaging industry, particularly for bottles and containers. Due to its chemical stability and durability, PET accumulates in the environment, contributing significantly to plastic pollution. It comprises repeating units of terephthalic acid and ethylene glycol, resulting in a semi-crystalline structure that is resistant to natural degradation processes.A notable breakthrough in plastic biodegradation came with the...
131
Functions of the Gut Microbiota01:18

Functions of the Gut Microbiota

233
The gut microbiota includes trillions of microorganisms that colonize the human gastrointestinal tract, including bacteria, archaea, viruses, and fungi. This complex ecosystem plays a critical role in maintaining intestinal and systemic health. Most of these microbes inhabit the large intestine, establishing a relatively stable and diverse community that contributes to gut homeostasis through various metabolic, immunological, and protective mechanisms.Dominant bacterial phyla, such as...
233
Gut-Brain Axis01:22

Gut-Brain Axis

222
The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such...
222

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nanoengineered Azotobacter <i>Pseudomonas stutzeri</i> A1501 for Soil Ecology Restoration and Biological Nitrogen Fixation.

ACS nano·2025
Same author

Enhanced bacteriostatic effects of phage vB_C4 and cell wall-targeting antibiotic combinations against drug-resistant <i>Aeromonas veronii</i>.

Microbiology spectrum·2025
Same author

A Dry Patch with <i>In Situ</i> Solid-to-Gel Transformation for All-in-One Skin Wound Care.

ACS applied materials & interfaces·2024
Same author

Correction to "Integrating Bacteria with a Ternary Combination of Photosensitizers for Monochromatic Irradiation-Mediated Photoacoustic Imaging-Guided Synergistic Photothermal Therapy".

ACS nano·2024
Same author

A Molecular Switch-Integrated Nanoplatform Enables Photo-Unlocked Antibacterial Drug Delivery for Synergistic Abscess Therapy.

Advanced healthcare materials·2023
Same author

<i>In Situ</i> Polymerization-Mediated Antigen Presentation.

Journal of the American Chemical Society·2023

Related Experiment Video

Updated: May 5, 2026

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
08:58

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis

Published on: January 5, 2017

12.2K

Engineered Probiotics Mitigate Gut Barrier Dysfunction Induced by Nanoplastics.

Wenxin Chen1, Qiyan Guo1, Hong Li1

  • 1School of Life and Health Sciences, Hainan Province Key Laboratory of One Health, Collaborative Innovation Center of One Health, Hainan University, Haikou, 570228, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|April 1, 2025
PubMed
Summary

This study developed a probiotic drug delivery system (EcNT@L) to combat gut barrier damage from nanoplastics (PET). The system effectively reduced inflammation and infections, offering a novel therapeutic approach for nanoplastic-induced gut dysfunctions.

Keywords:
engineered probioticsgut barrierintestinal florananoplactics

More Related Videos

Prospecting Microbial Strains for Bioremediation and Probiotics Development for Metaorganism Research and Preservation
09:49

Prospecting Microbial Strains for Bioremediation and Probiotics Development for Metaorganism Research and Preservation

Published on: October 31, 2019

22.3K
Assessment of Gut Barrier Integrity in Mice Using Fluorescein-Isothiocyanate-Labeled Dextran
05:14

Assessment of Gut Barrier Integrity in Mice Using Fluorescein-Isothiocyanate-Labeled Dextran

Published on: November 18, 2022

8.0K

Related Experiment Videos

Last Updated: May 5, 2026

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
08:58

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis

Published on: January 5, 2017

12.2K
Prospecting Microbial Strains for Bioremediation and Probiotics Development for Metaorganism Research and Preservation
09:49

Prospecting Microbial Strains for Bioremediation and Probiotics Development for Metaorganism Research and Preservation

Published on: October 31, 2019

22.3K
Assessment of Gut Barrier Integrity in Mice Using Fluorescein-Isothiocyanate-Labeled Dextran
05:14

Assessment of Gut Barrier Integrity in Mice Using Fluorescein-Isothiocyanate-Labeled Dextran

Published on: November 18, 2022

8.0K

Area of Science:

  • Environmental Science and Health
  • Microbiology
  • Biotechnology

Background:

  • Micro- and nanoplastics, especially polyethylene terephthalate (PET), compromise gut barrier integrity, increasing susceptibility to inflammation and infections.
  • Existing treatments for nanoplastic-induced gut issues are limited, necessitating innovative solutions.

Purpose of the Study:

  • To develop a probiotic-based drug delivery system (EcNT@L) to mitigate nanoplastic-induced gut barrier dysfunction.
  • To evaluate the efficacy of EcNT@L in protecting against and treating gastrointestinal inflammation and infections.

Main Methods:

  • Genetically engineered Escherichia coli Nissle 1917 (EcN) to produce transforming growth factor-β (TGF-β) and coated it with Eudragit L100-55 to create EcNT@L.
  • Assessed EcNT@L's protective effects on Caco-2 cells against nano PET-induced inflammation and infections via NF-κB pathway activation.
  • Evaluated in vivo therapeutic efficacy of EcNT@L in a mouse model of gastrointestinal infection combined with nano PET and Salmonella.

Main Results:

  • EcNT@L effectively protected Caco-2 cells from nano PET-induced inflammation and infections by activating the NF-κB signaling pathway.
  • In vivo studies showed EcNT@L outperformed commercial antibiotics in treating combined nano PET and Salmonella infection.
  • EcNT@L modulated immune responses and gut microbiota, demonstrating superior therapeutic effects.

Conclusions:

  • Probiotic-based drug delivery systems, like EcNT@L, show significant potential for addressing nanoplastic-induced gut dysfunctions.
  • EcNT@L offers a promising strategy to mitigate the health impacts of micro- and nanoplastics on the gastrointestinal system.