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Aggregation-induced emission bioconjugates are revolutionizing personalized medicine with advanced fluorescence imaging. This review highlights their preparation, properties, and applications in bioimaging.

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Chemistry

Background:

  • Fluorescence imaging is crucial for personalized and precision medicine.
  • Organic luminogens with aggregation-induced emission (AIE) characteristics (AIEgens) show promise.
  • AIE bioconjugates offer superior biocompatibility, processability, and signal-to-noise ratios for biological applications.

Purpose of the Study:

  • To review the recent advancements in AIE bioconjugates.
  • To discuss their preparation, properties, and applications.
  • To explore future challenges and opportunities in the field.

Main Methods:

  • Literature review focusing on the last five years of research.
  • Analysis of AIE bioconjugate synthesis and characterization.
  • Evaluation of AIE bioconjugate performance in various bioapplications.

Main Results:

  • AIE bioconjugates demonstrate excellent photophysical properties and biocompatibility.
  • Covalent linkage of AIEgens with biomolecules enhances targeting and imaging capabilities.
  • Significant progress has been made in their application across diverse biomedical fields.

Conclusions:

  • AIE bioconjugates are highly promising for advanced bioimaging in precision medicine.
  • Further research is needed to overcome existing challenges and unlock their full potential.
  • Continued development will drive innovation in diagnostic and therapeutic applications.