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Correlates of cancer-related fatigue in colorectal cancer patients at the time of diagnosis.

María Romero-Elías1, Alejandro Álvarez-Bustos2, Marta Méndez1,3

  • 1Instituto de Investigación Sanitaria Puerta de Hierro-Segovia de Arana (IDIPHISA), Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Spain.

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
|April 1, 2025
PubMed
Summary
This summary is machine-generated.

Cancer-related fatigue (CRF) affects one in four patients at diagnosis. Women report higher fatigue, which is linked to other symptoms and reduced quality of life, necessitating clinical attention.

Keywords:
Cancer patientsFatigueFitnessPhysical activityQuality of life

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Area of Science:

  • Oncology
  • Clinical Research
  • Patient-Reported Outcomes

Background:

  • Cancer-related fatigue (CRF) is a prevalent and debilitating symptom in cancer patients.
  • Understanding the factors associated with CRF at diagnosis is crucial for timely intervention.
  • Physical activity and condition are potential, but not fully elucidated, correlates of CRF.

Purpose of the Study:

  • To investigate the correlates of cancer-related fatigue (CRF) at the time of diagnosis in colorectal cancer (CRC) patients.
  • To specifically examine the relationship between CRF and physical activity and physical condition.
  • To identify patient characteristics and symptoms associated with CRF at diagnosis.

Main Methods:

  • A cohort of 238 patients (stages I-IV) with colon or rectum cancer were recruited.
  • Fatigue was assessed using the PERFORM multidimensional questionnaire (PQ).
  • Quality of life, diet, sociodemographics, physical activity (self-reported and accelerometer), and physical condition (objective tests) were also evaluated.

Main Results:

  • CRF was present in approximately 25% of CRC patients at diagnosis.
  • Higher CRF levels were associated with female sex, lower perceived health, being a retired woman, poorer quality of life, and hypercholesterolemia.
  • CRF correlated with symptoms like pain, anxiety, gastrointestinal issues, dyspnoea, and financial difficulties, but not with metastatic stage or objectively measured physical condition.

Conclusions:

  • CRF is common at CRC diagnosis, particularly in women, and significantly impacts quality of life.
  • The association of CRF with various symptoms highlights the need for comprehensive assessment.
  • Oncologists should routinely inquire about and document fatigue to ensure proper follow-up and management.