Fractional CO2 laser with topical insulin versus PRP for atrophic acne scars: a randomized split-face study

Area of Science:

• Dermatology
• Regenerative Medicine

Background:

• Atrophic acne scarring is a common concern, often requiring combination therapies for optimal results.
• Various treatments exist, but efficacy varies, highlighting the need for improved therapeutic strategies.

Purpose of the Study:

• To compare the efficacy of topical insulin versus topical platelet-rich plasma (PRP) as adjuncts to fractional CO2 laser therapy for atrophic acne scars.
• To evaluate the safety and synergistic effects of these combined treatment regimens.

Main Methods:

• A study involving 30 patients with atrophic acne scars.
• Four sessions of fractional CO2 laser treatment were administered, followed by application of topical PRP on one facial side and topical insulin on the other.
• Outcomes were assessed using the Acne Scar Assessment Scale (ASAS) by blinded dermatologists and patient self-assessment.

Main Results:

• Both topical insulin and topical PRP significantly improved atrophic acne scars when used as adjuncts to fractional CO2 laser therapy.
• No statistically significant difference in efficacy was observed between the topical insulin and topical PRP treatment groups (p=0.794).
• Both interventions demonstrated favorable safety profiles.

Conclusions:

• Topical insulin and topical PRP are both effective adjunct treatments for atrophic acne scars when combined with fractional CO2 laser.
• The study suggests a potential synergistic effect of these treatments, offering comparable efficacy and safety.
• Further research may explore optimal combinations for enhanced acne scar revision.