Generalized Pustular Psoriasis Brazilian Experts Survey: Challenges in Disease Management

Area of Science:

• Dermatology
• Immunology
• Clinical Medicine

Background:

• Generalized pustular psoriasis (GPP) is a rare, severe skin condition requiring complex diagnosis and management.
• Current GPP management lacks standardized guidelines, particularly in Brazil.
• Understanding Brazilian dermatologists' practices is crucial for improving patient care.

Purpose of the Study:

• To survey Brazilian dermatologists on their diagnostic and therapeutic approaches to GPP.
• To identify current management strategies, challenges, and unmet needs in GPP care within Brazil.

Main Methods:

• A questionnaire survey was distributed to 57 Brazilian dermatologists experienced in treating GPP.
• The survey covered diagnosis, treatment, and follow-up of GPP patients over the past five years.
• Data was collected from 32 responding dermatologists.

Main Results:

• Diagnosis relies on pustules, skin lesions, and erythema, with inflammatory markers aiding screening.
• Common triggers include steroid withdrawal, infection, and stress; flares average 2-4 weeks.
• Cyclosporine is favored for flares, retinoids for residual disease; many find current treatments slow and ineffective for flare prevention.
• Hospitalization is frequent and prolonged for Brazilian GPP patients.

Conclusions:

• GPP presents significant management challenges in Brazil, with longer hospitalizations than in Europe and the USA.
• There is an urgent need for a Brazilian consensus on GPP management goals and standards of care.
• Improved therapeutic options are required for faster GPP flare resolution and prevention.