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Increase in quinolones prescriptions for children (0-10 years old) in Brazil

Fernando S Del Fiol1, Jéssica Cristina B Noguerol Andrade1, Bianca G Belini1

  • 1Doctoral Program in Pharmaceutical Sciences, University of Sorocaba, Sorocaba, Brazil.

Journal of Infection in Developing Countries
|April 1, 2025
PubMed

Insights

Quinolone antibiotic use in Brazilian children (0-10 years) increased over 50%, significantly outpacing overall population growth. This rise highlights concerns regarding pediatric safety and the need for cautious prescribing of these drugs.

Area of Science:

  • Pediatric Pharmacology
  • Antimicrobial Stewardship
  • Public Health

Background:

  • Quinolones carry risks like tendinopathy and joint damage.
  • Pediatric safety data for quinolones is limited, restricting their recommended use.
  • Investigating quinolone consumption trends in children is crucial.

Purpose of the Study:

  • To analyze the trend of quinolone consumption in Brazilian children aged 0-10 years.
  • To compare pediatric quinolone use with the general population's consumption patterns.

Main Methods:

  • Interrupted time series analysis of quinolone consumption data.
  • Utilized data from the Brazilian National Controlled Products Management System (SNGPC).
  • Employed analysis of variance and joinpoint regression to assess sales variations.

Main Results:

  • Approximately 1 million quinolone units were prescribed to children (0-10 years) in Brazil.
  • Pediatric quinolone utilization surged by over 50%, significantly higher than the 24% increase in the general population.
  • Annual growth in pediatric quinolone use was approximately 9% year-on-year.

Conclusions:

  • A significant increase in quinolone prescriptions for young children in Brazil was observed.
  • Emphasizes the need for caution due to known risks and limited pediatric safety data.
  • Recommends prioritizing safer alternatives, promoting prudent prescribing, and further research for pediatric guidelines.
Abstract

Keywords:
childrenjoint damagequinolonestendinopathies

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