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Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
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Epidemiological and economical burden of cholestatic liver disease

Bregje Mol1,2, Ellen Werner3, Emma L Culver4

  • 1Department of Gastroenterology and Hepatology, Amsterdam University Medical Centre, Amsterdam, The Netherlands.

Hepatology (Baltimore, Md.)
|April 1, 2025
PubMed

Insights

Primary sclerosing cholangitis, primary biliary cholangitis, and IgG4-related cholangitis are increasingly important liver diseases. Understanding their epidemiology and patient impact is crucial as they rise in prevalence.

Area of Science:

  • Hepatology and Gastroenterology
  • Rare Diseases
  • Immunology

Background:

  • Cholestatic liver diseases, including primary sclerosing cholangitis (PSC), primary biliary cholangitis (PBC), and IgG4-related cholangitis (IgG4-AC), are gaining clinical significance.
  • Their incidence is rising, contrasting with declining viral hepatitis rates, making them a growing focus in hepatology.
  • These conditions are now a leading reason for liver transplantation in Western nations.

Purpose of the Study:

  • To offer a comprehensive review of the epidemiology of PSC, PBC, and IgG4-AC.
  • To examine the impact of these cholestatic liver diseases on health-related quality of life.
  • To assess the economic burden associated with PSC, PBC, and IgG4-AC.

Main Methods:

  • Systematic literature review of epidemiological data.
  • Analysis of studies reporting on quality of life in patients with PSC, PBC, and IgG4-AC.
  • Review of economic evaluations and cost-of-illness studies.

Main Results:

  • Cholestatic liver diseases represent a growing public health concern with increasing prevalence.
  • Patients with PSC, PBC, and IgG4-AC experience significant decrements in quality of life.
  • These diseases impose a substantial economic burden on healthcare systems and society.

Conclusions:

  • PSC, PBC, and IgG4-AC require greater attention due to their rising incidence and impact.
  • Further research into effective management strategies and patient support is warranted.
  • Addressing the quality of life and economic consequences is essential for comprehensive patient care.

Keywords:
IgG4-related cholangitisburden of diseaseeconomic burdenepidemiologyhealth related quality of lifeprimary biliary cholangitisprimary sclerosing cholangitis

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