Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Local Anesthetics: Differential Sensitivity of Nerve Fibers

Local Anesthetics: Differential Sensitivity of Nerve Fibers

Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The impact of acupuncturists' experience level on the efficacy of acupuncture for functional dyspepsia: an exploratory secondary analysis of a randomized clinical trial.

Frontiers in medicine·2026

Same author

rno-miR-199a-3p-Nedd4 signaling regulates mast cell-dependent peripheral sensitization in osteoarthritis pain.

Neuroscience·2026

Same author

Electroacupuncture alleviates myocardial ischemia-reperfusion injury by targeting and inhibiting NLRP3 inflammasome-mediated cardiomyocyte pyroptosis via serum exosomal miR-22-3p.

Frontiers in immunology·2026

Same author

Acupuncture for acute treatment of migraine without aura: A randomized clinical trial.

Headache·2026

Same author

Acupuncture for the Management of Postpartum Uterine Contraction Pain Following Vaginal Delivery: A Protocol for a Randomized, Sham-Controlled Trial.

Journal of pain research·2026

Same author

Acupuncture for amnestic mild cognitive impairment: Study protocol for a multicenter, single-blinded, long-term, randomized controlled trial.

PloS one·2026

Search research articles

Related Experiment Video

Updated: Jul 26, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Gray Matter Alterations in Medication Overuse Headache: A Voxel-Based Morphometry Meta-Analysis.

Weiming Luo¹, Yuke Teng¹, Xingyao Chen²

¹Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China; Key Laboratory of Acupuncture for Senile Disease (Chengdu University of TCM), Ministry of Education, Chengdu, Sichuan, China.

|April 1, 2025

Summary

Medication overuse headache (MOH) is linked to significant gray matter changes in the brain, including increased amounts in the cerebellum and reduced amounts in frontal regions. These findings offer insights into MOH

Keywords:

MRI gray matter neuroimagers meta-analysis neuroimaging voxel-based morphometry Medication overuse headache

More Related Videos

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

Author Spotlight: Deciphering Electrical Networks Behind Complex Brain Activities and Disorders

Author Spotlight: Deciphering Electrical Networks Behind Complex Brain Activities and Disorders

Published on: November 1, 2024

Related Experiment Videos

Last Updated: Jul 26, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

Author Spotlight: Deciphering Electrical Networks Behind Complex Brain Activities and Disorders

Author Spotlight: Deciphering Electrical Networks Behind Complex Brain Activities and Disorders

Published on: November 1, 2024

Area of Science:

Neuroimaging and Neurology
Brain Structure and Function

Background:

Medication overuse headache (MOH) is a secondary headache disorder.
Chronic pain medication use causes significant brain alterations in MOH.
Previous studies on gray matter (GM) changes in MOH show inconsistent results.

Purpose of the Study:

To conduct a comprehensive meta-analysis of voxel-based morphometry (VBM) neuroimaging studies on MOH.
To synthesize findings on whole-brain gray matter alterations in MOH patients.

Main Methods:

Systematic review and meta-analysis of 8 VBM studies.
Inclusion of 378 participants (191 MOH patients, 187 healthy controls).
Utilized activation likelihood estimation (ALE) and Anisotropic effect size-signed differential mapping (AES-SDM) for GM analysis.

Main Results:

MOH patients exhibited increased GM in the cerebellar vermis, left red nuclei, and right medial dorsal nuclei.
MOH patients showed reduced GM in left superior/inferior frontal gyri, right precunei, and bilateral middle frontal gyri.
Clinical variables like headache duration and frequency correlated with GM alterations.

Conclusions:

Significant GM alterations observed in brain regions involved in pain processing and reward in MOH.
Findings enhance understanding of MOH neural mechanisms and potential therapeutic targets.
Further research is needed to explore GM changes as potential biomarkers for MOH diagnosis and treatment.