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Updated: May 16, 2025

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
Asymmetric Synthesis of the Tetracyclic Core of Venezuelaene B
Louxi Chen1,2, Chao-Han Zhang1, Junyang Liu3
1Shenzhen Grubbs Institute, Department of Chemistry, Guangming Advanced Research Institute, Southern University of Science and Technology, Shenzhen 518055, China.
Abstract:
A concise and efficient approach for the asymmetric synthesis of the tetracyclic core of venezuelaene B is described. Its uncommon and synthetically challenging [5-5-6-7] tetracyclic skeleton was constructed via a mild acid-promoted type I [5+2] cycloaddition, followed by a diastereoselective intramolecular Pauson-Khand reaction. The described chemistry establishes the feasibility of constructing the [5-5-6-7] tetracyclic core and several desired stereocenters (C2, C10, C11, and C14) of the final product.
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