Early Recognition of Sepsis in Prehospital Settings: A Review of Screening Tools and Practices

Sepsis remains a global health challenge, with millions affected and high mortality rates. Early recognition is critical for improving outcomes, particularly in prehospital settings where timely interventions can significantly impact patient survival. This literature review examines screening tools used in prehospital environments, focusing on their predictive abilities, ease of use, and limitations in detecting sepsis. Tools such as the quick Sequential Organ Failure Assessment (qSOFA), National Early Warning Score (NEWS), National Early Warning Score 2 (NEWS2), Systemic Inflammatory Response Syndrome, and Monocyte Distribution Width offer varied strengths and applications in identifying sepsis. Research shows that NEWS and NEWS2 demonstrate higher sensitivity for predicting mortality, while qSOFA offers simplicity but may lack sensitivity outside of acute care settings. Differential diagnoses, such as pulmonary embolism and adrenal crisis, can mimic sepsis, making accurate assessment essential. The review highlights the role of Emergency Medical Services (EMS) and Family Nurse Practitioners in early detection and emphasizes the importance of evidence-based practices and clear protocols. This review aims to provide EMS and Nurse Practitioners with the knowledge and tools to recognize sepsis early, ensuring appropriate referrals and improving patient outcomes.