Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Psychological and Sociocultural Causes of Schizophrenia

Psychological and Sociocultural Causes of Schizophrenia

Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...

Biological Causes of Schizophrenia

Biological Causes of Schizophrenia

Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...

Negative and Cognitive Symptoms of Schizophrenia

Negative and Cognitive Symptoms of Schizophrenia

Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...

Neuroplasticity

Neuroplasticity

Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.

Schizophrenia

Schizophrenia

Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Aperiodic activity modulation during visual oddball paradigm in clinical high-risk individuals and relationship with psychosis conversion.

Schizophrenia research·2026

Same author

Regional homogeneity and interhemispheric connectivity alterations in major depressive disorder.

Asian journal of psychiatry·2026

Same author

The effects of rTMS over orbitofrontal cortex on cognitive functions in first-episode schizophrenia.

Psychological medicine·2026

Same author

Hyper-scanning and hyper-pursuit define eye movement biomarkers of anxiety disorders.

The British journal of psychiatry : the journal of mental science·2026

Same author

Cross-disorder brain morphological similarity in schizophrenia: Associations with symptom severity and treatment outcome.

Schizophrenia research·2026

Same author

Longitudinal investigation of the T helper (Th)1-Th2 balance and complement system in clinical high risk for psychosis cohort.

Translational psychiatry·2026

Search research articles

Related Experiment Video

Updated: May 16, 2025

Development of a Virtual Reality Assessment of Everyday Living Skills

Development of a Virtual Reality Assessment of Everyday Living Skills

Published on: April 23, 2014

Brain Network Resilience and Cognitive Function in Patients With First-Episode Schizophrenia Spectrum Disorders.

Soyolsaikhan Odkhuu¹, XiaoChen Tang², Woo-Sung Kim¹

¹Department of Psychiatry, Jeonbuk National University, Medical School, Jeonju, Korea.

Biological Psychiatry

|April 1, 2025

Summary

First-episode schizophrenia spectrum disorders (FESSDs) show reduced brain network robustness and resilience. Preserved network integrity correlates with better executive function and fewer symptoms, suggesting therapeutic targets.

Keywords:

Cognitive function First-episode schizophrenia spectrum disorders Resilience Robustness k-shell decomposition

More Related Videos

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

Related Experiment Videos

Last Updated: May 16, 2025

Development of a Virtual Reality Assessment of Everyday Living Skills

Development of a Virtual Reality Assessment of Everyday Living Skills

Published on: April 23, 2014

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

Area of Science:

Neuroscience
Psychiatry
Cognitive Science

Background:

First-episode schizophrenia spectrum disorders (FESSDs) present significant cognitive impairments impacting daily life.
Neural underpinnings of cognitive deficits in FESSDs are not fully understood.
Brain network robustness and resilience are linked to cognitive function in healthy individuals.

Purpose of the Study:

To investigate the association between brain network structure robustness, resilience, and cognitive function in FESSDs.
To explore these relationships in relation to psychopathology within FESSDs.

Main Methods:

Utilized k-shell decomposition on functional brain networks from 340 FESSDs patients across two cohorts (South Korea, China) and 420 healthy controls (HC).
Assessed structure robustness and resilience using advanced network analysis techniques.
Correlated network measures with cognitive function (executive function) and psychopathology (Positive and Negative Syndrome Scale).

Main Results:

FESSDs patients exhibited less robust and resilient brain networks compared to HC participants.
Resilience measures positively correlated with executive function in FESSDs.
Core brain network structure and k-core resilience were negatively correlated with symptom severity (Positive and Negative Syndrome Scale scores).
Site-specific analysis confirmed findings, with cognitive and psychopathology correlations observed primarily in the South Korea cohort.

Conclusions:

Enhanced preservation of brain network structure and resilience is linked to improved cognitive function and reduced clinical symptoms in FESSDs.
These findings identify potential therapeutic targets for cognitive enhancement and symptom management in FESSDs.