Related Experiment Video
Updated: May 16, 2025

Author Spotlight: Quantifying Pain Experience – An Illustrative Approach Using the Pain Body Diagram
Published on: July 7, 2023
Nociplastic pain: A practical guide to chronic pain management in the primary care setting
1Department of Rheumatology, Atrium Health Wake Forest Baptist Medical Center, Winston-Salem, NC; Assistant Professor, Wake Forest University School of Medicine, Winston-Salem, NC rthapa@wakehealth.edu.
Abstract:
Management of chronic pain is one of the most challenging medical issues in primary care. Effective pain management requires an understanding of nociplastic pain, a condition characterized by amplification of pain transmission and pain perception. Unlike nociceptive and neuropathic pain, nociplastic pain does not involve visible tissue injury or damage, which makes it difficult to understand and manage. This review discusses practical ways for primary care clinicians to identify and manage nociplastic pain at the point of care.
Related Concept Videos
Analgesia and Pain Management
Nociception
Opioid Analgesics: Synthetic and Semisynthetic Opioids
Pain
Opioid Analgesics: Morphine and Other Natural Cogeners
Local Anesthetics: Common Agents and Their Applications
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...

