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Iron-Catalyzed Site-Selective Bromination of Benzylic C(sp3)-H Bonds
Guangyi Zhang1, Zihao Xu1, Bing Han2
1School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China.
Abstract:
An iron-catalyzed chemo- and site-selective benzylic C-H bromination has been described. The practical approach uses the C-H substrate as the limiting reagent and commercially available iron(II) bromide at a loading of 1 mol % as the catalyst without the involvement of any extrinsic ligand. The simple and mild reaction can be readily scaled up to gram quantity with good functional group tolerance, offering a convenient route for the late-stage diversification of complex bioactive natural products and pharmaceutical molecules through sequential benzylic C-H bromination.
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