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Correlation between migraine and circulating platelet aggregates.

C Buttinelli, M P Lazzaro, G L Lenzi

    Cephalalgia : an International Journal of Headache
    |May 1, 1985
    PubMed
    Summary
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    Migraine patients exhibit significantly lower Platelet Aggregate Ratio (PAR) values, indicating increased platelet aggregation. This abnormality is most pronounced in the first week following a migraine attack.

    Area of Science:

    • Neurology
    • Hematology
    • Clinical Medicine

    Background:

    • Platelet aggregation plays a role in various vascular conditions.
    • Migraine is a complex neurological disorder with potential vascular components.

    Purpose of the Study:

    • To investigate platelet aggregate levels in migraine patients.
    • To determine if platelet aggregation differs between migraineurs and controls.
    • To explore the relationship between time since last migraine attack and platelet aggregation.

    Main Methods:

    • Utilized Wu and Hoak's technique to measure platelet aggregates.
    • Expressed platelet aggregation as Platelet Aggregate Ratio (PAR).
    • Assessed 73 migraine patients and 90 control subjects, defining pathological PAR as <86.

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    Main Results:

    • Migraine patients showed a significantly lower mean PAR (78.3) compared to controls (95.4) (p < 0.001).
    • Only 27.4% of migraine patients had normal PAR values.
    • PAR values were lowest in the first week post-migraine (73.76) and increased over time, approaching normal ranges by the third week.

    Conclusions:

    • Elevated platelet aggregation, indicated by low PAR, is a common finding in migraine patients.
    • Platelet aggregation levels appear to correlate with the time elapsed since the last migraine attack.
    • Further research is warranted to understand the clinical implications of altered platelet aggregation in migraine.