Related Experiment Video
Updated: May 16, 2025
05:06
Author Spotlight: Integrating Tai Chi with Mindfulness Training to Achieve an Effective Mind-Body Exercise
Published on: July 14, 2023
1.5K
COVID-19 and neuropathy in type 2 diabetes
Georgios Ponirakis1, Ibrahim Al-Janahi2, Einas Elgassim1
1Department of Medicine, Weill Cornell Medicine-Qatar, Qatar Foundation, Doha, Qatar.
Scientific Reports
|April 1, 2025
Summary
COVID-19 did not worsen diabetic peripheral neuropathy in type 2 diabetes patients. However, factors like low blood pressure, elevated lipids, and female gender were linked to developing long-COVID symptoms.
Area of Science:
- Endocrinology
- Neurology
- Infectious Diseases
Background:
- Diabetic peripheral neuropathy (DPN) is a common complication of type 2 diabetes (T2D).
- The impact of COVID-19 on DPN in T2D patients remains unclear.
- Investigating risk factors for COVID-19 and its sequelae in T2D is crucial.
Purpose of the Study:
- To determine the risk factors for COVID-19 in T2D patients.
- To assess the impact of COVID-19 on the development and progression of DPN.
- To identify predictors of severe COVID-19 and long-COVID in this population.
Main Methods:
- Prospective study of 76 T2D patients.
- Assessments included NICE post-COVID questionnaire, DN4, vibration perception threshold (VPT), and corneal confocal microscopy (CCM).
- Data collected pre-COVID-19 and at follow-up (11.0 ± 8.9 months post-COVID-19).
Main Results:
- 35% of patients developed COVID-19, with 22.9% severe and 25.7% long-COVID.
- COVID-19 development was linked to lower systolic blood pressure.
- No association found between DPN and COVID-19, severe COVID-19, or long-COVID.
- Women were more likely to develop long-COVID; elevated body weight, LDL, and VPT were also associated.
- Long-COVID group showed significant changes in triglycerides, LDL, and body weight.
- Corneal nerve measures significantly reduced in both COVID-19 and non-COVID-19 groups.
Conclusions:
- COVID-19 does not appear to impact the development or progression of DPN in T2D patients.
- Low systolic blood pressure, altered lipids, body weight, higher VPT, and gender may influence COVID-19 outcomes in T2D.
- Further research is needed to understand the long-term effects of COVID-19 on T2D complications.
Keywords:
COVID-19Corneal confocal microscopyCorneal nerve measuresDiabetic peripheral neuropathySevere COVID-19Type 2 diabeteslong-COVIDMore Related Videos
06:21Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid
Published on: April 7, 2023
1.3K
09:39Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
Published on: February 13, 2018
9.5K
Related Concept Videos
01:22Diabetes Mellitus: Overview and Type I Subtype
2.3K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.3K
01:22Diabetes Mellitus: Type 2 and Gestational
2.1K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.1K
01:20Pathophysiology of Diabetes
822
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
822
01:15Diabetes: Symptoms, Diagnosis, and Complications
488
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
488
01:36Carbohydrate Metabolism
10.6K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
10.6K
01:19Psychoneuroimmunology: Diabetes and Cancer
19
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
19