Micro-nanoplastic induced cardiovascular disease and dysfunction: a scoping review

Area of Science:

• Environmental Health
• Toxicology
• Cardiovascular Science

Background:

• Human bioaccumulation of micro- and nano-plastics (MNPs) is linked to disease.
• MNPs are increasingly recognized in human pathophysiology.

Purpose of the Study:

• To comprehensively review studies on MNP impacts on the human cardiovascular system.
• To synthesize current research on MNP presence and effects in cardiovascular tissues.

Main Methods:

• Systematic scoping review of five major scientific databases.
• Included studies investigating MNP presence and effects in human cardiovascular systems.

Main Results:

• Forty-six articles were identified; 13 focused on MNP presence in cardiovascular tissues like plaques and blood.
• In vitro studies indicate MNPs possess cytotoxic, immunotoxic, and genotoxic properties.
• MNPs may induce endothelial damage, alter lipid profiles, and affect clotting.

Conclusions:

• MNPs may contribute to cardiovascular morbidity and mortality.
• Potential roles in vascular diseases, congenital abnormalities, and cardiomyopathies are suggested.
• More research is crucial to characterize MNP presence and inform clinical strategies.