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The Current Landscape of 1,2,3-triazole Hybrids With Anticancer Therapeutic Potential: Part II

Zhi Xu1, Junna Liu2

  • 1Huanghuai University Industry Innovation & Research and Development Institute, Huanghuai University, Zhumadian, Henan, China.

Archiv Der Pharmazie
|April 2, 2025
PubMed

Insights

1,2,3-Triazole hybrids show promise as novel anticancer agents, effectively targeting multiple cancer pathways and overcoming drug resistance. This review explores their potential in cancer therapy, highlighting recent advancements.

Area of Science:

  • Medicinal Chemistry
  • Oncology
  • Drug Discovery

Background:

  • Chemotherapy is crucial for cancer treatment but faces challenges like multidrug resistance and severe side effects.
  • There is a critical need for novel therapeutic agents that can target multiple biological pathways in cancer.
  • 1,2,3-Triazole hybrids are emerging as promising scaffolds for developing new anticancer drugs.

Purpose of the Study:

  • To provide a comprehensive overview of 1,2,3-triazole hybrids as anticancer agents.
  • To discuss the in vitro and in vivo anticancer potential of these compounds.
  • To analyze structure-activity relationships and mechanisms of action for 1,2,3-triazole hybrids.

Main Methods:

  • Literature review of scientific articles published from 2021 onward.
  • Analysis of studies reporting the synthesis and biological evaluation of 1,2,3-triazole hybrids.
  • Examination of structure-activity relationships and proposed mechanisms of action.

Main Results:

  • 1,2,3-Triazole hybrids demonstrate significant potential for dual/multiple target engagement in cancer cells.
  • These compounds exhibit potent broad-spectrum anticancer activity, including efficacy against drug-resistant cancer types.
  • Recent research highlights diverse mechanisms through which these hybrids exert their cytotoxic effects.

Conclusions:

  • 1,2,3-Triazole hybrids represent a valuable scaffold for developing next-generation cancer therapeutics.
  • Their multitargeting capability offers a promising strategy to overcome current limitations in cancer treatment.
  • Further research into 1,2,3-triazole hybrids is warranted to fully exploit their therapeutic potential.
Keywords:
1,2,3‐triazolecancerhybridsmechanisms of actionstructure–activity relationship

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