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Cannabidiol and Its Effects on Patients with COVID-19 Infection

Yuval Kuntzman1, Gilad Halpert2, Howard Amital3

  • 1Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel, Internal Medicine B, Sheba Medical Center, Tel Hashomer, Israel.

The Israel Medical Association Journal : IMAJ
|April 2, 2025
PubMed
Abstract

Insights

Cannabidiol (CBD) improved clinical outcomes for patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). While CBD showed promise, its impact on specific inflammatory cytokines requires further investigation.

Area of Science:

  • Immunology and Virology
  • Pharmacology and Therapeutics

Background:

  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease progression is significantly modulated by inflammatory cytokines.
  • Cannabidiol (CBD) is recognized for its immunomodulatory properties, suggesting potential therapeutic applications.

Purpose of the Study:

  • To evaluate the efficacy of cannabidiol (CBD) in patients diagnosed with SARS-CoV-2.
  • To quantify the impact of CBD on key serum inflammatory cytokine levels in SARS-CoV-2 patients.

Main Methods:

  • A double-blind, placebo-controlled study design was employed.
  • Sublingual CBD extract was administered to seven SARS-CoV-2 patients, with three receiving a placebo.
  • Clinical outcomes and serum cytokine concentrations were compared between the treatment and placebo groups.

Main Results:

  • Patients treated with sublingual CBD demonstrated improved clinical outcomes compared to the placebo group.
  • Serum cytokine levels exhibited differences between groups, but with inconsistent trends.
  • The study involved a small sample size (7 CBD, 3 placebo).

Conclusions:

  • Sublingual administration of CBD was associated with better clinical outcomes in SARS-CoV-2 patients versus placebo.
  • Observed clinical improvements did not consistently correlate with changes in the selected serum cytokines.
  • Further research is warranted to elucidate the precise mechanisms and clinical significance of CBD in SARS-CoV-2 management.

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