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Updated: May 16, 2025

Detection of Architectural Distortion in Prior Mammograms via Analysis of Oriented Patterns
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Errors Induced by Partial Pathlength Variations Due to Mammographic Compression in Dynamic Diffuse Optical Breast

Kaiser Niknam1, Mannu Bardhan Paul2, Anthony Donaldson1

  • 1Department of Physics, University of Houston, Houston, TX.

Proceedings of Spie--The International Society for Optical Engineering
|April 2, 2025
PubMed
Summary
This summary is machine-generated.

Continuous-wave near-infrared spectroscopic imaging (CW-NIRS) shows promise for breast cancer screening by detecting hemodynamic differences. This study investigates and corrects compression-induced errors in CW-NIRS measurements for improved accuracy.

Keywords:
Near-infrared diffuse imagingNear-infrared spectroscopic imagingbreast imagingmammographic compressiontissue optics

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Area of Science:

  • Biomedical Optics
  • Medical Imaging
  • Cancer Diagnostics

Background:

  • Current breast imaging methods have limitations.
  • Mammographic compression affects breast tissue hemodynamics differently in cancerous versus healthy tissue.
  • Continuous-wave near-infrared spectroscopic imaging (CW-NIRS) can leverage these hemodynamic differences for breast cancer screening.

Purpose of the Study:

  • To investigate the impact of breast compression on CW-NIRS measurements.
  • To quantify errors introduced by tissue displacement during compression.
  • To develop and validate methods for correcting these compression-induced errors in CW-NIRS data.

Main Methods:

  • Utilized simulations and experimental data to analyze errors in CW-NIRS.
  • Examined how errors vary with signal depth under breast compression.
  • Investigated specific correction techniques for NIRS measurements.

Main Results:

  • Breast compression introduces significant errors in CW-NIRS measurements due to tissue displacement.
  • The magnitude of these errors is dependent on signal depth.
  • Correction methods were explored to mitigate these errors.

Conclusions:

  • Compression-induced errors are a critical challenge for CW-NIRS breast cancer screening.
  • Understanding and correcting these errors is essential for accurate blood volume estimation.
  • This work provides a foundation for developing more robust CW-NIRS techniques for breast cancer detection.